methyl (2S,4R)-4-{[bis(benzyloxy)phosphoryl]methyl}-5-oxotetrahydrofuran-2-carboxylate

Base Information

Chemical Name:methyl (2S,4R)-4-{[bis(benzyloxy)phosphoryl]methyl}-5-oxotetrahydrofuran-2-carboxylate
CAS No.:1312438-90-6
Molecular Formula:C₂₁H₂₃O₇P
Molecular Weight:418.383
Hs Code.:

Synonyms:methyl (2S,4R)-4-{[bis(benzyloxy)phosphoryl]methyl}-5-oxotetrahydrofuran-2-carboxylate

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Chemical Property of methyl (2S,4R)-4-{[bis(benzyloxy)phosphoryl]methyl}-5-oxotetrahydrofuran-2-carboxylate

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Technology Process of methyl (2S,4R)-4-{[bis(benzyloxy)phosphoryl]methyl}-5-oxotetrahydrofuran-2-carboxylate

There total 4 articles about methyl (2S,4R)-4-{[bis(benzyloxy)phosphoryl]methyl}-5-oxotetrahydrofuran-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312438-86-0
dimethyl (2R,4S)-2-{[bis(benzyloxy)phosphoryl]methyl}-4-{[tert-butyl(dimethyl)silyl]oxy}pentanedioate

: 1312438-90-6
methyl (2S,4R)-4-{[bis(benzyloxy)phosphoryl]methyl}-5-oxotetrahydrofuran-2-carboxylate

Guidance literature:: dimethyl (2R,4S)-2-{[bis(benzyloxy)phosphoryl]methyl}-4-{[tert-butyl(dimethyl)silyl]oxy}pentanedioate; With (1S)-10-camphorsulfonic acid; In methanol; at 20 ℃; for 18h;

With (1S)-10-camphorsulfonic acid; In toluene; at 20 ℃;

Reference yield:

: 17176-77-1
Dibenzyl phosphite

: 1312438-90-6
methyl (2S,4R)-4-{[bis(benzyloxy)phosphoryl]methyl}-5-oxotetrahydrofuran-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 - 90 °C

2.1: Chiralpak IC / isopropyl alcohol; hexane / 20 °C / Resolution of racemate

3.1: (1S)-10-camphorsulfonic acid / methanol / 18 h / 20 °C

3.2: 20 °C

With (1S)-10-camphorsulfonic acid; potassium carbonate; In methanol; hexane; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1312438-82-6
dimethyl (S)-2-{[tert-butyl(dimethyl)silyl]oxy}-4-methylenepentanedioate

: 1312438-90-6
methyl (2S,4R)-4-{[bis(benzyloxy)phosphoryl]methyl}-5-oxotetrahydrofuran-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 - 90 °C

2.1: Chiralpak IC / isopropyl alcohol; hexane / 20 °C / Resolution of racemate

3.1: (1S)-10-camphorsulfonic acid / methanol / 18 h / 20 °C

3.2: 20 °C

With (1S)-10-camphorsulfonic acid; potassium carbonate; In methanol; hexane; N,N-dimethyl-formamide; isopropyl alcohol;