Cyclobutanecarboxylic acid, 3-ethynyl-3-hydroxy-1-methyl-, cis- (9CI)

Base Information

Chemical Name:Cyclobutanecarboxylic acid, 3-ethynyl-3-hydroxy-1-methyl-, cis- (9CI)
CAS No.:286442-92-0
Molecular Formula:C₈H₁₀O₃
Molecular Weight:154.166
Hs Code.:
Mol file:286442-92-0.mol

Synonyms:Cyclobutanecarboxylic acid, 3-ethynyl-3-hydroxy-1-methyl-, cis- (9CI)

Suppliers and Price of Cyclobutanecarboxylic acid, 3-ethynyl-3-hydroxy-1-methyl-, cis- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Synthonix
cis-3-Ethynyl-3-hydroxy-1-methylcyclobutanecarboxylicacid 95+%
1g
$ 1860.00

Crysdot
cis-3-Ethynyl-3-hydroxy-1-methylcyclobutane-carboxylicacid 95+%
100mg
$ 361.00

Chemenu
cis-3-Ethynyl-3-hydroxy-1-methylcyclobutane-carboxylicacid 95%
100mg
$ 341.00

Total 6 raw suppliers

Chemical Property of Cyclobutanecarboxylic acid, 3-ethynyl-3-hydroxy-1-methyl-, cis- (9CI)

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

cis-3-Ethynyl-3-hydroxy-1-methylcyclobutanecarboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Cyclobutanecarboxylic acid, 3-ethynyl-3-hydroxy-1-methyl-, cis- (9CI)

There total 3 articles about Cyclobutanecarboxylic acid, 3-ethynyl-3-hydroxy-1-methyl-, cis- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: cis- and trans-3-hydroxy-1-methyl-3-trimethylsilylethynylcyclobutanecarboxylic acid

: 286442-92-0,286443-22-9
cis- and trans-3-ethynyl-3-hydroxy-1-methylcyclobutanecarboxylic acid

Guidance literature:: With sodium hydroxide; In methanol; at 20 ℃;
DOI:10.1016/S0968-0896(00)00034-1

Reference yield:

: 286442-89-5
1-methyl-3-oxocyclobutane-1-carboxylic acid

: 286442-92-0,286443-22-9
cis- and trans-3-ethynyl-3-hydroxy-1-methylcyclobutanecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / hexane; tetrahydrofuran / 0.5 h / -78 °C

1.2: 84 percent / tetrahydrofuran; hexane / -78 - 20 °C

2.1: 70 percent / aq. NaOH / methanol / 20 °C

With sodium hydroxide; n-butyllithium; In tetrahydrofuran; methanol; hexane; 1.1: Metallation / 1.2: Addition / 2.1: Hydrolysis;
DOI:10.1016/S0968-0896(00)00034-1

Reference yield:

: 286442-86-2
1-methyl-3-methylidenecyclobutanecarboxylic acid

: 286442-92-0,286443-22-9
cis- and trans-3-ethynyl-3-hydroxy-1-methylcyclobutanecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: O₃ / CH₂Cl₂ / 0.5 h / -78 °C

1.2: 75 percent / Me₂S / CH₂Cl₂ / 20 °C

2.1: n-BuLi / hexane; tetrahydrofuran / 0.5 h / -78 °C

2.2: 84 percent / tetrahydrofuran; hexane / -78 - 20 °C

3.1: 70 percent / aq. NaOH / methanol / 20 °C

With sodium hydroxide; n-butyllithium; ozone; In tetrahydrofuran; methanol; hexane; dichloromethane; 1.1: Oxidation / 1.2: Ring cleavage / 2.1: Metallation / 2.2: Addition / 3.1: Hydrolysis;
DOI:10.1016/S0968-0896(00)00034-1