1H-Pyrrole-2-methanol,alpha,1-dimethyl-,(-)-(9CI)

Base Information

• Chemical Name: 1H-Pyrrole-2-methanol,alpha,1-dimethyl-,(-)-(9CI)
• CAS No.: 286415-02-9
• Molecular Formula: C₇H₁₁NO
• Molecular Weight: 125.17
• Mol file: 286415-02-9.mol

Synonyms:1H-Pyrrole-2-methanol,alpha,1-dimethyl-,(-)-(9CI)

Chemical Property of 1H-Pyrrole-2-methanol,alpha,1-dimethyl-,(-)-(9CI)

Chemical Property:

Purity/Quality:

α,1-dimethyl-1H-Pyrrole-2-methanol 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-Pyrrole-2-methanol,alpha,1-dimethyl-,(-)-(9CI)

There total 6 articles about 1H-Pyrrole-2-methanol,alpha,1-dimethyl-,(-)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-methyl-2-acetylpyrrole (932-16-1) → 2-(1-hydroxyethyl)-1-methylpyrrole (56423-58-6,286415-02-9,544713-09-9)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 20 ℃; for 1.5h;

DOI:10.1021/jf034369u

Reference yield: 99.0%

N-methyl-2-acetylpyrrole (932-16-1) → (R)-1-(N-methylpyrrol-2-yl)ethan-1-ol (544713-08-8,286415-02-9,544713-09-9)

Guidance literature:

With C₃₇H₄₀MnN₂O₂P₂⁽¹⁺⁾*Br^(1-); sodium t-butanolate; In isopropyl alcohol; at 50 ℃; for 2h; enantioselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1002/anie.201912605

Reference yield: 51.0%

N-methyl-2-acetylpyrrole (932-16-1) → (S)-1-[2-(1-methylpyrrolyl)]ethanol (286415-02-9,544713-09-9)

Guidance literature:

With potassium tert-butylate; hydrogen; trans-RuCl₂[(R)-xylbinap][(R)-daipen]; In isopropyl alcohol; tert-butyl alcohol; at 25 ℃; for 20h; under 6080.41 Torr;

DOI:10.1021/ol0000814

upstream raw materials:

N-methylpyrrole aldehyde

methyl magnesium iodide

N-methyl-2-acetylpyrrole

Refernces

• 1、 Li, Chun,Lu, Xunhua,Wang, Mengna,Zhang, Ling,Jiang, Jian,Yan, Shunfa,Yang, Yuanyong,Zhao, Yonglong,Zhang, Lin. "A simple and efficient asymmetric hydrogenation of heteroaromatic ketones with iridium catalyst composed of chiral diamines and achiral phosphines". . . Retrieved 2020/09/02.
• 2、 Rojo, Maria Victoria,Guetzoyan, Lucie,Baxendale, Ian. R.. "A monolith immobilised iridium Cp catalyst for hydrogen transfer reactions under flow conditions". . p. 1768 - 1777. Retrieved 2015/02/19.