tert-butyl 3-(N-{[N-((1S)-1-{N-[(2S)-2-(naphthylmethyl)pent-4-enyl]carbamoyl}-2-carbamoylethyl)carbamoyl]cyclohexyl}carbamoyl)-(3S,4S)-4-(4-{[bis(tert-butoxy)phosphono]methyl}phenyl)hex-5-enoate

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Chemical Name:tert-butyl 3-(N-{[N-((1S)-1-{N-[(2S)-2-(naphthylmethyl)pent-4-enyl]carbamoyl}-2-carbamoylethyl)carbamoyl]cyclohexyl}carbamoyl)-(3S,4S)-4-(4-{[bis(tert-butoxy)phosphono]methyl}phenyl)hex-5-enoate
CAS No.:495404-50-7
Molecular Formula:C₅₃H₇₅N₄O₉P
Molecular Weight:943.174
Hs Code.:

tert-butyl 3-(N-{[N-((1S)-1-{N-[(2S)-2-(naphthylmethyl)pent-4-enyl]carbamoyl}-2-carbamoylethyl)carbamoyl]cyclohexyl}carbamoyl)-(3S,4S)-4-(4-{[bis(tert-butoxy)phosphono]methyl}phenyl)hex-5-enoate

Synonyms:tert-butyl 3-(N-{[N-((1S)-1-{N-[(2S)-2-(naphthylmethyl)pent-4-enyl]carbamoyl}-2-carbamoylethyl)carbamoyl]cyclohexyl}carbamoyl)-(3S,4S)-4-(4-{[bis(tert-butoxy)phosphono]methyl}phenyl)hex-5-enoate

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Chemical Property of tert-butyl 3-(N-{[N-((1S)-1-{N-[(2S)-2-(naphthylmethyl)pent-4-enyl]carbamoyl}-2-carbamoylethyl)carbamoyl]cyclohexyl}carbamoyl)-(3S,4S)-4-(4-{[bis(tert-butoxy)phosphono]methyl}phenyl)hex-5-enoate

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Technology Process of tert-butyl 3-(N-{[N-((1S)-1-{N-[(2S)-2-(naphthylmethyl)pent-4-enyl]carbamoyl}-2-carbamoylethyl)carbamoyl]cyclohexyl}carbamoyl)-(3S,4S)-4-(4-{[bis(tert-butoxy)phosphono]methyl}phenyl)hex-5-enoate

There total 7 articles about tert-butyl 3-(N-{[N-((1S)-1-{N-[(2S)-2-(naphthylmethyl)pent-4-enyl]carbamoyl}-2-carbamoylethyl)carbamoyl]cyclohexyl}carbamoyl)-(3S,4S)-4-(4-{[bis(tert-butoxy)phosphono]methyl}phenyl)hex-5-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 401810-35-3
(2S)-N-[(2S)-2-(naphthylmethyl)pent-4-enyl]-2-[(aminocyclohexyl)carbonylamino]-3-carbamoylpropanamide

: 495404-40-5
(2S,3S)-3-(4-{[bis(tert-butoxy)phosphono]methyl}phenyl)-2-{[(tert-butyl)oxycarbonyl]methyl}pent-4-enoic acid

: 495404-50-7
tert-butyl 3-(N-{[N-((1S)-1-{N-[(2S)-2-(naphthylmethyl)pent-4-enyl]carbamoyl}-2-carbamoylethyl)carbamoyl]cyclohexyl}carbamoyl)-(3S,4S)-4-(4-{[bis(tert-butoxy)phosphono]methyl}phenyl)hex-5-enoate

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm0203635

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 495404-50-7
tert-butyl 3-(N-{[N-((1S)-1-{N-[(2S)-2-(naphthylmethyl)pent-4-enyl]carbamoyl}-2-carbamoylethyl)carbamoyl]cyclohexyl}carbamoyl)-(3S,4S)-4-(4-{[bis(tert-butoxy)phosphono]methyl}phenyl)hex-5-enoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaHMDS / tetrahydrofuran / 0.5 h / -78 °C

1.2: 77 percent / tetrahydrofuran / 2 h / -78 °C

2.1: 85 percent / aq. H₂O₂; aq. LiOH / tetrahydrofuran / 0 - 20 °C

3.1: 72 percent / HOAt; EDCI / dimethylformamide / 20 °C

With lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; dihydrogen peroxide; sodium hexamethyldisilazane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm0203635

Reference yield:

: 162648-54-6
1-[((9H-fluoren-9-yl)methoxy)carbonylamino]cyclohexanecarboxylic acid

: 495404-50-7
tert-butyl 3-(N-{[N-((1S)-1-{N-[(2S)-2-(naphthylmethyl)pent-4-enyl]carbamoyl}-2-carbamoylethyl)carbamoyl]cyclohexyl}carbamoyl)-(3S,4S)-4-(4-{[bis(tert-butoxy)phosphono]methyl}phenyl)hex-5-enoate

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / HOBt; DIPCDI / dimethylformamide / 20 °C

2: piperidine / acetonitrile / 2 h / 20 °C

3: 72 percent / HOAt; EDCI / dimethylformamide / 20 °C

With piperidine; 1-hydroxy-7-aza-benzotriazole; 1,3-di-tert-butylcarbodiimide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm0203635