(R)-2-((1R,2R,3S)-2-Methoxymethoxy-1,3-dimethyl-5-trityloxy-pentyl)-oxirane

Base Information

Chemical Name:(R)-2-((1R,2R,3S)-2-Methoxymethoxy-1,3-dimethyl-5-trityloxy-pentyl)-oxirane
CAS No.:112031-76-2
Molecular Formula:C₃₀H₃₆O₄
Molecular Weight:460.613
Hs Code.:

Synonyms:(R)-2-((1R,2R,3S)-2-Methoxymethoxy-1,3-dimethyl-5-trityloxy-pentyl)-oxirane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-((1R,2R,3S)-2-Methoxymethoxy-1,3-dimethyl-5-trityloxy-pentyl)-oxirane

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Technology Process of (R)-2-((1R,2R,3S)-2-Methoxymethoxy-1,3-dimethyl-5-trityloxy-pentyl)-oxirane

There total 13 articles about (R)-2-((1R,2R,3S)-2-Methoxymethoxy-1,3-dimethyl-5-trityloxy-pentyl)-oxirane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 112031-80-8
(2R,3R,4S)-4-Methyl-2-(R)-oxiranyl-6-trityloxy-hexan-3-ol

: 107-30-2
chloromethyl methyl ether

: 112031-76-2
(R)-2-((1R,2R,3S)-2-Methoxymethoxy-1,3-dimethyl-5-trityloxy-pentyl)-oxirane

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine;
DOI:10.1016/S0040-4039(00)95311-5

Reference yield:

: 112031-74-0
(3S,4S,5R)-3-Hydroxy-4-methyl-5-((S)-1-methyl-3-trityloxy-propyl)-dihydro-furan-2-one

: 112031-76-2
(R)-2-((1R,2R,3S)-2-Methoxymethoxy-1,3-dimethyl-5-trityloxy-pentyl)-oxirane

Guidance literature:: Multi-step reaction with 4 steps

1: DMAP, pyridine

2: 75 percent / NaBH₄ / tetrahydrofuran; H₂O

3: NaOMe / methanol

4: 73 percent / (i-Pr)2EtN, DMAP

With pyridine; dmap; sodium tetrahydroborate; sodium methylate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; water;
DOI:10.1016/S0040-4039(00)95311-5

Reference yield:

: (S)-5-((S)-1-Methyl-3-trityloxy-propyl)-3-phenylselanyl-dihydro-furan-2-one

: 112031-76-2
(R)-2-((1R,2R,3S)-2-Methoxymethoxy-1,3-dimethyl-5-trityloxy-pentyl)-oxirane

Guidance literature:: Multi-step reaction with 8 steps

1: H₂O₂ / CH₂Cl₂

2: 83 percent / tetrahydrofuran / -78 °C

3: 1.) LHMDS, 2.) MoOPh / THF, -78 deg C

4: Ra-Ni

5: DMAP, pyridine

6: 75 percent / NaBH₄ / tetrahydrofuran; H₂O

7: NaOMe / methanol

8: 73 percent / (i-Pr)2EtN, DMAP

With pyridine; dmap; sodium tetrahydroborate; MoO₅*pyridine*HMPA; Ra-Ni; dihydrogen peroxide; sodium methylate; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1016/S0040-4039(00)95311-5