Methanesulfonic acid (1S,2R,3R,4S)-3-hydroxy-1-hydroxymethyl-2,4-dimethyl-6-trityloxy-hexyl ester

Base Information

Chemical Name:Methanesulfonic acid (1S,2R,3R,4S)-3-hydroxy-1-hydroxymethyl-2,4-dimethyl-6-trityloxy-hexyl ester
CAS No.:112031-75-1
Molecular Formula:C₂₉H₃₆O₆S
Molecular Weight:512.667
Hs Code.:

Synonyms:Methanesulfonic acid (1S,2R,3R,4S)-3-hydroxy-1-hydroxymethyl-2,4-dimethyl-6-trityloxy-hexyl ester

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Chemical Property of Methanesulfonic acid (1S,2R,3R,4S)-3-hydroxy-1-hydroxymethyl-2,4-dimethyl-6-trityloxy-hexyl ester

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Technology Process of Methanesulfonic acid (1S,2R,3R,4S)-3-hydroxy-1-hydroxymethyl-2,4-dimethyl-6-trityloxy-hexyl ester

There total 11 articles about Methanesulfonic acid (1S,2R,3R,4S)-3-hydroxy-1-hydroxymethyl-2,4-dimethyl-6-trityloxy-hexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: Methanesulfonic acid (3S,4R,5R)-4-methyl-5-((S)-1-methyl-3-trityloxy-propyl)-2-oxo-tetrahydro-furan-3-yl ester

: 112031-75-1
Methanesulfonic acid (1S,2R,3R,4S)-3-hydroxy-1-hydroxymethyl-2,4-dimethyl-6-trityloxy-hexyl ester

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; water;
DOI:10.1016/S0040-4039(00)95311-5

Reference yield:

: 112031-74-0
(3S,4S,5R)-3-Hydroxy-4-methyl-5-((S)-1-methyl-3-trityloxy-propyl)-dihydro-furan-2-one

: 112031-75-1
Methanesulfonic acid (1S,2R,3R,4S)-3-hydroxy-1-hydroxymethyl-2,4-dimethyl-6-trityloxy-hexyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: DMAP, pyridine

2: 75 percent / NaBH₄ / tetrahydrofuran; H₂O

With pyridine; dmap; sodium tetrahydroborate; In tetrahydrofuran; water;
DOI:10.1016/S0040-4039(00)95311-5

Reference yield:

: (S)-5-((S)-1-Methyl-3-trityloxy-propyl)-3-phenylselanyl-dihydro-furan-2-one

: 112031-75-1
Methanesulfonic acid (1S,2R,3R,4S)-3-hydroxy-1-hydroxymethyl-2,4-dimethyl-6-trityloxy-hexyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: H₂O₂ / CH₂Cl₂

2: 83 percent / tetrahydrofuran / -78 °C

3: 1.) LHMDS, 2.) MoOPh / THF, -78 deg C

4: Ra-Ni

5: DMAP, pyridine

6: 75 percent / NaBH₄ / tetrahydrofuran; H₂O

With pyridine; dmap; sodium tetrahydroborate; MoO₅*pyridine*HMPA; Ra-Ni; dihydrogen peroxide; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/S0040-4039(00)95311-5