6-benzyloxycarbonylamino-2-(4-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-butyrylamino)-hexanoic acid tert-butyl ester

Base Information

Chemical Name:6-benzyloxycarbonylamino-2-(4-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-butyrylamino)-hexanoic acid tert-butyl ester
CAS No.:616883-55-7
Molecular Formula:C₃₂H₄₅Cl₂N₃O₅
Molecular Weight:622.632
Hs Code.:

6-benzyloxycarbonylamino-2-(4-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-butyrylamino)-hexanoic acid <i>tert</i>-butyl ester

Synonyms:6-benzyloxycarbonylamino-2-(4-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-butyrylamino)-hexanoic acid tert-butyl ester

Suppliers and Price of 6-benzyloxycarbonylamino-2-(4-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-butyrylamino)-hexanoic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 6-benzyloxycarbonylamino-2-(4-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-butyrylamino)-hexanoic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6-benzyloxycarbonylamino-2-(4-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-butyrylamino)-hexanoic acid tert-butyl ester

There total 1 articles about 6-benzyloxycarbonylamino-2-(4-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-butyrylamino)-hexanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 5978-22-3,1426213-63-9
N(ε)-benzoyloxycarbonyl-L-lysine tert-butyl ester hydrochloride

: 305-03-3
chlorambucil

: 616883-55-7
6-benzyloxycarbonylamino-2-(4-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-butyrylamino)-hexanoic acid tert-butyl ester

Guidance literature:: With 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/S0968-0896(03)00057-9

Reference yield:

: 616883-55-7
6-benzyloxycarbonylamino-2-(4-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-butyrylamino)-hexanoic acid tert-butyl ester

: 6-amino-2-(4-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-butyrylamino)-hexanoic acid tert-butyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 2h;
DOI:10.1016/S0968-0896(03)00057-9

Reference yield:

: 616883-55-7
6-benzyloxycarbonylamino-2-(4-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-butyrylamino)-hexanoic acid tert-butyl ester

: (S)-2-(4-{4-[Bis-(2-chloro-ethyl)-amino]-phenyl}-butyrylamino)-6-[3-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-propionylamino]-hexanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd/C / methanol / 2 h / 20 °C

2: 227 mg / 4-methylmorpholine; HBTU / dimethylformamide / 20 °C

3: TFA / CH₂Cl₂ / 0 °C

With 4-methyl-morpholine; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(03)00057-9