305-03-3Relevant articles and documents
A two-photon responsive naphthyl tagged: P -hydroxyphenacyl based drug delivery system: Uncaging of anti-cancer drug in the phototherapeutic window with real-time monitoring
Kundu, Moumita,Mondal, Mahitosh,Nair, Asha V,Pal, Bipul,Roy, Biswajit,Roy, Samrat,Shah, Sk. Sheriff,Singh, Amit Kumar,Singh, N. D. Pradeep
, p. 9986 - 9989 (2020)
We report a two-photon responsive drug delivery system (DDS), namely, p-hydroxyphenacyl-naphthalene-chlorambucil (pHP-Naph-Cbl), having a two-photon absorption (TPA) cross-section of ≥20 GM in the phototherapeutic window (700 nm). Our DDS exhibited both AIE and ESIPT phenomena, which were utilized for the real-time monitoring of anti-cancer drug release.
Single component photoresponsive fluorescent organic nanoparticles: a smart platform for improved biomedical and agrochemical applications
Chaudhuri, Amrita,Paul, Amrita,Sikder, Antara,Pradeep Singh
, p. 1715 - 1733 (2021)
In the last two decades, light responsive nano drug delivery systems (DDSs) have gained considerable importance, particularly in the area of biology and medicine. In general, light responsive nano DDSs are bicomponent and constructed using two ingredients, namely a nanocarrier and a phototrigger. The synthesis of these bicomponent nano DDSs requires multiple steps, which limits their applications. Hence, we have reported single component light responsive nano DDSs using fluorescent organic nanoparticles (FONPs) which acted both as a nanocarrier and a phototrigger. This feature article provides an overview of recently developed light responsive single component FONPs and their applications in the regulated release of anticancer drugs, gasotransmitters, antibacterial agents, and pesticides, and also as efficient PDT agents. We have summarised the synthesis, characterisation, and photophysical, photochemical, andin vitrobehaviours of these light responsive FONPs. In addition, we also discussed the advantages of using FONPs as a nano DDS for cellular studies like: excellent biocompatibility, efficient cellular internalisation, real time monitoring of the drug release ability inside the cells, and enhanced cytotoxicity due to regulated release of bioactive molecules inside the cells.
Targeted photoresponsive carbazole–coumarin and drug conjugates for efficient combination therapy in leukemia cancer cells
Chang, Wen-Wei,Chu, Chih-Chien,Lai, Yi-Ting,Lin, Yen-Cheng,Ou, Jia-Yu,Wang, Bing-Yen
, (2020)
Phototriggered drug delivery systems (PTDDSs) facilitate controlled delivery of drugs loaded on photoactive platform to the target region under light stimulation. The present study investigated the synthesis and efficacy of carbazole–coumarin (CC)-fused heterocycles as a PTDDS platform for the photocontrolled release of a chemotherapeutic agent, chlorambucil, in an in vitro model of human breast and leukemia cancer cells. CC-fused heterocycles were constructed using 4-hydroxycarbazole as the starting material, and further modification of these heterocycles yielded two CC derivatives. CC-7 with an additional ? COOH group and CC-8 with the triphenylphosphonium (TPP) group, a mitochondria-targeting ligand introduced in the carbazole ring, dissolved in polar solvents and exhibited emission bands at 360 and 450 nm, respectively. The results indicate that visible light of 405 nm triggers the photolysis of the CC–drug conjugate and efficiently delivers the drug in both in vitro cancer cell models. Cytotoxicity evaluation indicates the suppression of proliferation of both types of cells treated with CC-8 under synergy effect combining drug potency and photosensitization. Further, the lower IC50 of CC-8 toward leukemia cells suggests the efficacy of the TPP ligand in increasing the bioavailability of CC–drug conjugates in leukemia treatment. Studies on mitochondria-targeting drug delivery systems are required for improving the performance of anticancer drugs.
Cys fluorescent molecular probe for detecting DNA targeting under reduction stress as well as preparation method and application of Cys fluorescent molecular probe
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Paragraph 0067-0068, (2021/06/26)
The invention relates to a Cys fluorescent molecular probe for detecting DNA targeting under reduction stress as well as a preparation method and application of the Cys fluorescent molecular probe. The structural formula of the fluorescent molecular probe is as shown in the formula (1). The prominent light control characteristic of the fluorescent molecular probe is beneficial to real-time monitoring of diseases caused by errors in the DNA replication process due to abnormal expression of Cys under DNA peripheral reduction stress, and the fluorescent molecular probe is expected to be applied to prevention, treatment and the like of gene diseases caused by abnormal expression of Cys.
PHOTOLYTIC COMPOUNDS AND TRIPLET-TRIPLET ANNIHILATION MEDIATED PHOTOLYSIS
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Paragraph 0026; 00254, (2021/04/17)
The invention provides novel photolytic compounds and prodrugs, nanoparticles and compositions thereof, and methods of conducting photolysis mediated by triplet-triplet annihilation.