(R)-tert-butyl 3-(2-hydroxyethyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:(R)-tert-butyl 3-(2-hydroxyethyl)pyrrolidine-1-carboxylate
CAS No.:1212182-03-0
Molecular Formula:C₁₁H₂₁NO₃
Molecular Weight:215.293
Hs Code.:
Mol file:1212182-03-0.mol

Synonyms:tert-butyl (3R)-3-(2-hydroxyethyl)pyrrolidine-1-carboxylate

Suppliers and Price of (R)-tert-butyl 3-(2-hydroxyethyl)pyrrolidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R)-N-Boc-3-(2-hydroxyethyl)pyrrolidine
10mg
$ 45.00

Chemenu
(R)-1-Boc-3-(2-hydroxyethyl)pyrrolidine 95%
1g
$ 554.00

American Custom Chemicals Corporation
(3R)-1-BOC-3-(2-HYDROXYETHYL)PYRROLIDINE 95.00%
0.25G
$ 374.00

Alichem
(R)-tert-Butyl3-(2-hydroxyethyl)pyrrolidine-1-carboxylate
5g
$ 1762.78

Alichem
(R)-tert-Butyl3-(2-hydroxyethyl)pyrrolidine-1-carboxylate
1g
$ 587.24

Total 11 raw suppliers

Chemical Property of (R)-tert-butyl 3-(2-hydroxyethyl)pyrrolidine-1-carboxylate

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

(R)-N-Boc-3-(2-hydroxyethyl)pyrrolidine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-tert-butyl 3-(2-hydroxyethyl)pyrrolidine-1-carboxylate

There total 4 articles about (R)-tert-butyl 3-(2-hydroxyethyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 204688-60-8
(R)-3-carboxymethyl-pyrrolidin-1-carboxylic acid tert-butyl ester

: 1212182-03-0
tert-butyl (3R)-3-(2-hydroxyethyl)pyrrolidine-1-carboxylate

Guidance literature:: (R)-3-carboxymethyl-pyrrolidin-1-carboxylic acid tert-butyl ester; With borane-THF; In tetrahydrofuran; at 23 - 28 ℃; for 2.75h; Inert atmosphere;

With sodium hydroxide; In tetrahydrofuran; water; at 10 - 25 ℃; for 1.66667h; Product distribution / selectivity;

Reference yield:

: 127423-61-4
tert-butyl (3R)-3-methylsulfonyloxypyrrolidine-1-carboxylate

: 1212182-03-0
tert-butyl (3R)-3-(2-hydroxyethyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 35 - 40 °C

1.2: 18 h / 65 °C

1.3: pH 3 - 4

2.1: diethyl malonate; potassium hydroxide / water; tetrahydrofuran / 25 - 45 °C

2.2: 0.5 h / 5 - 10 °C

3.1: dimethyl sulfoxide / toluene / 2 h / Reflux

4.1: borane-THF / tetrahydrofuran / 2.75 h / 23 - 28 °C / Inert atmosphere

4.2: 1.67 h / 10 - 25 °C

With borane-THF; potassium tert-butylate; dimethyl sulfoxide; diethyl malonate; potassium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; water; toluene;

Reference yield:

: 1228312-12-6
2-((R)-1-tert-butoxycarbonyl-pyrrolidin-3-yl)-malonic acid diethyl ester

: 1212182-03-0
tert-butyl (3R)-3-(2-hydroxyethyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: diethyl malonate; potassium hydroxide / water; tetrahydrofuran / 25 - 45 °C

1.2: 0.5 h / 5 - 10 °C

2.1: dimethyl sulfoxide / toluene / 2 h / Reflux

3.1: borane-THF / tetrahydrofuran / 2.75 h / 23 - 28 °C / Inert atmosphere

3.2: 1.67 h / 10 - 25 °C

With borane-THF; dimethyl sulfoxide; diethyl malonate; potassium hydroxide; In tetrahydrofuran; water; toluene;