(R)-2-(1-(tert-butoxycarbonyl)pyrrolidin-3-yl)Malonic acid

Base Information

Chemical Name:(R)-2-(1-(tert-butoxycarbonyl)pyrrolidin-3-yl)Malonic acid
CAS No.:1228312-13-7
Molecular Formula:C12H19NO6
Molecular Weight:273.28236
Hs Code.:
Mol file:1228312-13-7.mol

Synonyms:(R)-2-(1-(tert-butoxycarbonyl)pyrrolidin-3-yl)Malonic acid

Suppliers and Price of (R)-2-(1-(tert-butoxycarbonyl)pyrrolidin-3-yl)Malonic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of (R)-2-(1-(tert-butoxycarbonyl)pyrrolidin-3-yl)Malonic acid

Chemical Property:

Purity/Quality:: 99.3% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (R)-2-(1-(tert-butoxycarbonyl)pyrrolidin-3-yl)Malonic acid

There total 4 articles about (R)-2-(1-(tert-butoxycarbonyl)pyrrolidin-3-yl)Malonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.1%

: 1228312-12-6
2-((R)-1-tert-butoxycarbonyl-pyrrolidin-3-yl)-malonic acid diethyl ester

: 1228312-13-7
2-((R)-1-tert-butoxycarbonyl-pyrrolidin-3-yl)-malonic acid

Guidance literature:: 2-((R)-1-tert-butoxycarbonyl-pyrrolidin-3-yl)-malonic acid diethyl ester; With water; potassium hydroxide; In tetrahydrofuran; at 25 - 45 ℃;

With hydrogenchloride; In water; at 5 - 10 ℃; for 0.5h; pH=2; Product distribution / selectivity;

Reference yield: 54.0%

: 127423-61-4
tert-butyl (3R)-3-methylsulfonyloxypyrrolidine-1-carboxylate

: 105-53-3
diethyl malonate

: 1228312-13-7
2-((R)-1-tert-butoxycarbonyl-pyrrolidin-3-yl)-malonic acid

Guidance literature:: diethyl malonate; With sodium ethanolate; In ethanol; at 40 ℃; for 1.5h;

tert-butyl (3R)-3-methylsulfonyloxypyrrolidine-1-carboxylate; In ethanol; at 78 ℃; for 8h;

Reference yield:

: 127423-61-4
tert-butyl (3R)-3-methylsulfonyloxypyrrolidine-1-carboxylate

: 1228312-13-7
2-((R)-1-tert-butoxycarbonyl-pyrrolidin-3-yl)-malonic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 35 - 40 °C

1.2: 18 h / 65 °C

1.3: pH 3 - 4

2.1: diethyl malonate; potassium hydroxide / water; tetrahydrofuran / 25 - 45 °C

2.2: 0.5 h / 5 - 10 °C

With potassium tert-butylate; diethyl malonate; potassium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; water;