2-Bromo-4-{4-(quinolin-3-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzonitrile

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Chemical Name:2-Bromo-4-{4-(quinolin-3-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzonitrile
CAS No.:1260535-39-4
Molecular Formula:C₂₃H₁₁BrF₃N₅
Molecular Weight:494.273
Hs Code.:

Synonyms:2-Bromo-4-{4-(quinolin-3-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzonitrile

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Chemical Property of 2-Bromo-4-{4-(quinolin-3-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzonitrile

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Technology Process of 2-Bromo-4-{4-(quinolin-3-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzonitrile

There total 5 articles about 2-Bromo-4-{4-(quinolin-3-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 36282-26-5
2-bromo-4-fluorobenzonitrile

: 1260535-36-1
3-{3-(Trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-4-yl}quinoline

: 1260535-39-4
2-Bromo-4-{4-(quinolin-3-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzonitrile

Guidance literature:: 3-{3-(Trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-4-yl}quinoline; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.5h;

2-bromo-4-fluorobenzonitrile; In N,N-dimethyl-formamide; mineral oil; at 60 ℃; for 1h;

Reference yield:

: 956010-87-0
3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine

: 1260535-39-4
2-Bromo-4-{4-(quinolin-3-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: 3-chloro-benzenecarboperoxoic acid / 1,2-dimethoxyethane; n-heptane / 1 h / 0 - 20 °C

2.1: trichlorophosphate / 1 h / 100 °C

2.2: pH 10 / Cooling with ice

3.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 3 h / 100 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

4.2: 1 h / 60 °C

With sodium hydride; sodium carbonate; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; 1,2-dimethoxyethane; n-heptane; water; N,N-dimethyl-formamide; mineral oil; 3.1: Suzuki Coupling;

Reference yield:

: 1260535-32-7
3-(Trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine 7-oxide

: 1260535-39-4
2-Bromo-4-{4-(quinolin-3-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate / 1 h / 100 °C

1.2: pH 10 / Cooling with ice

2.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 3 h / 100 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

3.2: 1 h / 60 °C

With sodium hydride; sodium carbonate; trichlorophosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; N,N-dimethyl-formamide; mineral oil; 2.1: Suzuki Coupling;