(E)-tert-butyl 6-(4-methoxy-3-(methoxycarbamoyl)-5-methylphenyl)-6-(tributylstannyl)hex-5-enoate

Base Information

Chemical Name:(E)-tert-butyl 6-(4-methoxy-3-(methoxycarbamoyl)-5-methylphenyl)-6-(tributylstannyl)hex-5-enoate
CAS No.:945965-68-4
Molecular Formula:C₃₂H₅₅NO₅Sn
Molecular Weight:652.502
Hs Code.:

Synonyms:(E)-tert-butyl 6-(4-methoxy-3-(methoxycarbamoyl)-5-methylphenyl)-6-(tributylstannyl)hex-5-enoate

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Chemical Property of (E)-tert-butyl 6-(4-methoxy-3-(methoxycarbamoyl)-5-methylphenyl)-6-(tributylstannyl)hex-5-enoate

Chemical Property:

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Technology Process of (E)-tert-butyl 6-(4-methoxy-3-(methoxycarbamoyl)-5-methylphenyl)-6-(tributylstannyl)hex-5-enoate

There total 6 articles about (E)-tert-butyl 6-(4-methoxy-3-(methoxycarbamoyl)-5-methylphenyl)-6-(tributylstannyl)hex-5-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 945965-67-3
(E)-5-(6-tert-butoxy-6-oxo-1-(tributylstannyl)hex-1-enyl)-2-methoxy-3-methylbenzoic acid

: 593-56-6
N-methoxylamine hydrochloride

: 945965-68-4
(E)-tert-butyl 6-(4-methoxy-3-(methoxycarbamoyl)-5-methylphenyl)-6-(tributylstannyl)hex-5-enoate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 15h;

Reference yield:

: 945965-65-1
methyl 5-(5-tert-butoxycarbonyl-pent-1-ynyl)-2-methoxy-3-methylbenzoate

: 945965-68-4
(E)-tert-butyl 6-(4-methoxy-3-(methoxycarbamoyl)-5-methylphenyl)-6-(tributylstannyl)hex-5-enoate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 2 h / 20 °C

2: lithium hydroxide; water / 1,4-dioxane / 22 h / 60 °C

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 15 h / 20 °C

With dmap; lithium hydroxide; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane;

Reference yield:

: 53293-00-8
hex-5-ynoic acid

: 945965-68-4
(E)-tert-butyl 6-(4-methoxy-3-(methoxycarbamoyl)-5-methylphenyl)-6-(tributylstannyl)hex-5-enoate

Guidance literature:: Multi-step reaction with 5 steps

1: dmap / tert-butyl alcohol / 2 h / 20 °C

2: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 12 h / 0 - 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 2 h / 20 °C

4: lithium hydroxide; water / 1,4-dioxane / 22 h / 60 °C

5: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 15 h / 20 °C

With dmap; lithium hydroxide; copper(l) iodide; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; tert-butyl alcohol; 2: Sonogashira Coupling;