(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-mercaptoacetate

Base Information

• Chemical Name: (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-mercaptoacetate
• CAS No.: 74441-18-2
• Molecular Formula: C₁₂H₂₂O₂S
• Molecular Weight: 230.371
• Mol file: 74441-18-2.mol

Synonyms:(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-mercaptoacetate

Chemical Property of (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-mercaptoacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-mercaptoacetate

There total 2 articles about (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-mercaptoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(-)-menthol (2216-51-5) + mercaptoacetic acid (68-11-1) → (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-mercaptoacetate (74441-18-2)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; for 2h; Reflux;

DOI:10.1021/acs.oprd.0c00145

Reference yield:

2-(2,6-dimethyl-5-heptenyl)-1,3-oxathiolan-5-one (125364-82-1) → Mercapto-acetic acid (2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester (58473-86-2,74441-18-2)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; Heating;

DOI:10.1016/S0040-4039(00)99222-0

Reference yield: 92.0%

Pentafluoropyridine (700-16-3) + (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-mercaptoacetate (74441-18-2) → (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-((perfluoropyridin-4-yl)thio)acetate

Guidance literature:

With triethylamine; In acetonitrile; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/acs.joc.1c02897

upstream raw materials:

2-(2,6-dimethyl-5-heptenyl)-1,3-oxathiolan-5-one

(-)-menthol

mercaptoacetic acid

Downstream raw materials:

DL-neomenthol

menthol

α-campholenic aldehyde acetal

Acetoxy-ethylsulfanyl-acetic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester