(E)-ethyl 3-(4-((E)-2-phenyl-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylate

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Chemical Name:(E)-ethyl 3-(4-((E)-2-phenyl-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylate
CAS No.:1365889-01-5
Molecular Formula:C₃₃H₃₄N₂O₃
Molecular Weight:506.645
Hs Code.:

Synonyms:(E)-ethyl 3-(4-((E)-2-phenyl-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylate

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Chemical Property of (E)-ethyl 3-(4-((E)-2-phenyl-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylate

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Technology Process of (E)-ethyl 3-(4-((E)-2-phenyl-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylate

There total 6 articles about (E)-ethyl 3-(4-((E)-2-phenyl-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 850568-49-9
(E)-(4-(3-ethoxy-3-oxoprop-1-en-1-yl)phenyl)boronic acid

: 591-50-4
iodobenzene

: 1365889-00-4
5-(but-1-yn-1-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole

: 1365889-01-5
(E)-ethyl 3-(4-((E)-2-phenyl-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylate

Guidance literature:: With potassium carbonate; bis(benzonitrile)palladium(ll) chloride; In water; N,N-dimethyl-formamide; at 45 ℃; Inert atmosphere;

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 1365889-01-5
(E)-ethyl 3-(4-((E)-2-phenyl-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridinium p-toluenesulfonate / dichloromethane / 48 h / 20 °C / Inert atmosphere

2: caesium carbonate; copper(l) iodide / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / ISOPROPYLAMIDE / 5 h / 80 °C / Inert atmosphere

3: potassium carbonate / bis(benzonitrile)palladium(ll) chloride / N,N-dimethyl-formamide; water / 45 °C / Inert atmosphere

With copper(l) iodide; pyridinium p-toluenesulfonate; potassium carbonate; caesium carbonate; 1,1'-bis-(diphenylphosphino)ferrocene; bis(benzonitrile)palladium(ll) chloride; palladium diacetate; In dichloromethane; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide;

Reference yield:

: 53857-57-1
5-bromo-1H-indazole

: 1365889-01-5
(E)-ethyl 3-(4-((E)-2-phenyl-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridinium p-toluenesulfonate / dichloromethane / 48 h / 20 °C / Inert atmosphere

2: caesium carbonate; copper(l) iodide / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / ISOPROPYLAMIDE / 5 h / 80 °C / Inert atmosphere

3: potassium carbonate / bis(benzonitrile)palladium(ll) chloride / N,N-dimethyl-formamide; water / 45 °C / Inert atmosphere

With copper(l) iodide; pyridinium p-toluenesulfonate; potassium carbonate; caesium carbonate; 1,1'-bis-(diphenylphosphino)ferrocene; bis(benzonitrile)palladium(ll) chloride; palladium diacetate; In dichloromethane; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide;