850568-49-9

Usage

Uses

Used in Organic Synthesis:
ETHYL 4-BORONOCINNAMATE is used as a building block for the synthesis of complex organic molecules, leveraging its reactivity in various chemical reactions to form a diverse range of boron-containing compounds.
Used in Pharmaceutical Industry:
ETHYL 4-BORONOCINNAMATE is used as a key reagent in drug development, contributing to the creation of new pharmaceuticals with potential therapeutic applications.
Used in Materials Science:
ETHYL 4-BORONOCINNAMATE is used as a precursor in the synthesis of novel organic materials, which may have unique properties and applications in various fields.
Used in Chemical Reactions:
ETHYL 4-BORONOCINNAMATE is used as a reactant in reactions such as Suzuki-Miyaura coupling, palladium-catalyzed cross-coupling, and C-H activation, facilitating the formation of new chemical bonds and structures.

InChI:InChI=1/C11H13BO4/c1-2-16-11(13)8-5-9-3-6-10(7-4-9)12(14)15/h3-8,14-15H,2H2,1H3/b8-5+

Upstream product

• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 87199-17-5 4-formylphenylboronic acid, 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 

Downstream Products

• 911301-35-4 (E/Z)-ethyl 2-azido-3-(4-boronophenyl)acrylate 
• 111771-55-2 C₁₁H₁₆BNO₄ 
• 1365889-01-5 (E)-ethyl 3-(4-((E)-2-phenyl-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylate 
• 34633-08-4 (E)-ethyl 3-(4-iodophenyl)prop-2-enoate 

Relevant academic research and scientific papers

Preparation method of 4-(E3-ethoxyl-3-oxo-1-propylene-1-yl) borophenylic acid

The invention relates the technical field of medical intermediates, and in particular relates to a preparation method of 4-(E3-ethoxyl-3-oxo-1-propylene-1-yl) borophenylic acid. By taking 4-formylphenylboronic acid as a raw material, a Wittig-Horner reaction is performed to obtain a target product, namely 4-(E3-ethoxyl-3-oxo-1-propylene-1-yl) borophenylic acid. The yield of the 4-(E3-ethoxyl-3-oxo-1-propylene-1-yl) borophenylic acid can reach about 80%. Moreover, lithium chloride and a DBU organic reagent which are low in price and are easily available are adopted, so that a low-temperature operation is avoided; and the preparation method is mild in reaction condition, simple in post-treatment process and suitable for industrial application.

Synthesis of phenylalanine analogs

A straight forward synthesis of phenylalanine analogs is described. Cerium ammonium nitrate (CAN) mediated addition of azide to cinnamicester, followed by reaction with sodium acetate aff orded the α-azidocinnamate in moderate yield. Hydrogenation of α-azidocinnamate, followed by BOC, CBZ or Fmoc protection gave phenylalanine analogs. A new approach for synthesizing racemic p-boronophenylalanine analog was also explored.