4-(8-isobutyl-5,6,7-trimethoxy-2-methyl-4-oxo-4H-chromen-3-yl)-benzoic acid

Base Information

Chemical Name:4-(8-isobutyl-5,6,7-trimethoxy-2-methyl-4-oxo-4H-chromen-3-yl)-benzoic acid
CAS No.:853577-70-5
Molecular Formula:C₂₄H₂₆O₇
Molecular Weight:426.466
Hs Code.:

4-(8-isobutyl-5,6,7-trimethoxy-2-methyl-4-oxo-4<i>H</i>-chromen-3-yl)-benzoic acid

Synonyms:4-(8-isobutyl-5,6,7-trimethoxy-2-methyl-4-oxo-4H-chromen-3-yl)-benzoic acid

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Chemical Property of 4-(8-isobutyl-5,6,7-trimethoxy-2-methyl-4-oxo-4H-chromen-3-yl)-benzoic acid

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Technology Process of 4-(8-isobutyl-5,6,7-trimethoxy-2-methyl-4-oxo-4H-chromen-3-yl)-benzoic acid

There total 6 articles about 4-(8-isobutyl-5,6,7-trimethoxy-2-methyl-4-oxo-4H-chromen-3-yl)-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 853577-63-6
3-iodo-8-isobutyl-5,6,7-trimethoxy-2-methyl-4H-chromen-4-one

: 14047-29-1
4-carboxyphenylboronic acid

: 853577-70-5
4-(8-isobutyl-5,6,7-trimethoxy-2-methyl-4-oxo-4H-chromen-3-yl)-benzoic acid

Guidance literature:: With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂;
DOI:10.1016/j.tetlet.2005.03.143

Reference yield:

: 853577-59-0
1-(6-hydroxy-2,3,4-trimethoxyphenyl)-2-methylpropan-1-one

: 853577-70-5
4-(8-isobutyl-5,6,7-trimethoxy-2-methyl-4-oxo-4H-chromen-3-yl)-benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: Et₃SiH / trifluoroacetic acid

2: 87 percent / BF₃*Et₂O

3: 76 percent / CH₂CO₂Na

4: 57 percent / Na₂CO₃ / H₂O / Heating

5: 95 percent / I₂; CF₃CO₂Ag

6: 75 percent / Na₂CO₃ / Pd(dpf)2Cl₂-CH₂Cl₂

With triethylsilane; boron trifluoride diethyl etherate; iodine; silver trifluoroacetate; sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In water; trifluoroacetic acid; 2: Friedel-Crafts reaction / 6: Suzuki coupling reaction;
DOI:10.1016/j.tetlet.2005.03.143

Reference yield:

: 853577-60-3
1-(2-hydroxy-3-isobutyl-4,5,6-trimethoxy-phenyl)-ethanone

: 853577-70-5
4-(8-isobutyl-5,6,7-trimethoxy-2-methyl-4-oxo-4H-chromen-3-yl)-benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 76 percent / CH₂CO₂Na

2: 57 percent / Na₂CO₃ / H₂O / Heating

3: 95 percent / I₂; CF₃CO₂Ag

4: 75 percent / Na₂CO₃ / Pd(dpf)2Cl₂-CH₂Cl₂

With iodine; silver trifluoroacetate; sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In water; 4: Suzuki coupling reaction;
DOI:10.1016/j.tetlet.2005.03.143