2-[3-(tert-butyldimethylsilanyloxy)phenyl]-2-methylpropionaldehyde

Base Information

• Chemical Name: 2-[3-(tert-butyldimethylsilanyloxy)phenyl]-2-methylpropionaldehyde
• CAS No.: 268233-94-9
• Molecular Formula: C₁₆H₂₆O₂Si
• Molecular Weight: 278.467
• Mol file: 268233-94-9.mol

Synonyms:2-[3-(tert-butyldimethylsilanyloxy)phenyl]-2-methylpropionaldehyde

Chemical Property of 2-[3-(tert-butyldimethylsilanyloxy)phenyl]-2-methylpropionaldehyde

Chemical Property:

Purity/Quality:

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Technology Process of 2-[3-(tert-butyldimethylsilanyloxy)phenyl]-2-methylpropionaldehyde

There total 1 articles about 2-[3-(tert-butyldimethylsilanyloxy)phenyl]-2-methylpropionaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-[3-(tert-butyldimethylsilanyloxy)phenyl]-2-methylpropan-1-ol (268234-40-8) → 2-[3-(tert-butyldimethylsilanyloxy)phenyl]-2-methylpropionaldehyde (268233-94-9)

Guidance literature:

With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 0.25h;

2-[3-(tert-butyldimethylsilanyloxy)phenyl]-2-methylpropan-1-ol; In dichloromethane; for 0.5h;

With triethylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield: 99.0%

ethyl (2E)-4-(diethoxyphosphoryl)crotonate (42516-28-9) + 2-[3-(tert-butyldimethylsilanyloxy)phenyl]-2-methylpropionaldehyde (268233-94-9) → ethyl (2E,4E)-6-[3-(tert-butyldimethylsilanyloxy)phenyl]-6-methylhepta-2,4-dienoate (268233-95-0)

Guidance literature:

ethyl (2E)-4-(diethoxyphosphoryl)crotonate; With lithium diisopropyl amide; In tetrahydrofuran; at 0 ℃; for 0.5h;

2-[3-(tert-butyldimethylsilanyloxy)phenyl]-2-methylpropionaldehyde; In tetrahydrofuran; at 20 ℃; for 4h;

Reference yield: 78.0%

diethoxyphosphoryl-acetic acid ethyl ester (867-13-0) + 2-[3-(tert-butyldimethylsilanyloxy)phenyl]-2-methylpropionaldehyde (268233-94-9) → ethyl (E)-4-[3-(tert-butyldimethylsilanyloxy)phenyl]-4-methylpent-2-enoate (268234-41-9)

Guidance literature:

diethoxyphosphoryl-acetic acid ethyl ester; With lithium diisopropyl amide; In tetrahydrofuran; at 0 ℃; for 0.5h;

2-[3-(tert-butyldimethylsilanyloxy)phenyl]-2-methylpropionaldehyde; In tetrahydrofuran; at 20 ℃; for 15h;

upstream raw materials:

2-[3-(tert-butyldimethylsilanyloxy)phenyl]-2-methylpropan-1-ol

Downstream raw materials:

ethyl (E)-4-[3-(tert-butyldimethylsilanyloxy)phenyl]-4-methylpent-2-enoate

ethyl (2E,4E)-6-[3-(tert-butyldimethylsilanyloxy)phenyl]-6-methylhepta-2,4-dienoate