42516-28-9

Basic information

• Product Name: TRIETHYL 4-PHOSPHONOCROTONATE
• Synonyms: trans-Ethyl-4-(diethylphosphono)crotonate, min. 90 % (E/Z:95/5);trans-Ethyl-4-(diethylphosphono)crotonate, min.
• CAS NO: 42516-28-9
• Molecular Formula: C₁₀H₁₉O₅P
• Molecular Weight: 250.2286
• Mol File: 42516-28-9.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 352.9°C at 760 mmHg
• Flash Point: 167.6°C
• Appearance: /
• Density: 1.099g/cm³
• Vapor Pressure: 3.71E-05mmHg at 25°C
• Refractive Index: 1.445
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: TRIETHYL 4-PHOSPHONOCROTONATE(CAS DataBase Reference)
• NIST Chemistry Reference: TRIETHYL 4-PHOSPHONOCROTONATE(42516-28-9)
• EPA Substance Registry System: TRIETHYL 4-PHOSPHONOCROTONATE(42516-28-9)

Safety Data

• Hazardous Substances Data: 42516-28-9(Hazardous Substances Data)

Usage

General Description

Triethyl 4-phosphonocrotonate is a chemical compound commonly used as a phosphonate ester. It is a colorless to pale yellow liquid with a mild, fruity odor. TRIETHYL 4-PHOSPHONOCROTONATE is widely employed as a building block in the synthesis of various organic molecules, particularly in the production of pharmaceuticals, agrochemicals, and other fine chemicals. Additionally, it is used as a solvent and an intermediate in organic synthesis. Triethyl 4-phosphonocrotonate is known for its ability to participate in a variety of chemical reactions, making it a versatile compound in the field of organic chemistry. However, it is important to handle this compound with care due to its potential hazards, and proper safety precautions should be observed when working with it.

InChI:InChI=1/C10H19O5P/c1-4-13-10(11)8-7-9-16(12,14-5-2)15-6-3/h7-8H,4-6,9H2,1-3H3

Upstream product

• 37746-78-4 4-bromo-trans-crotonic acid ethyl ester 
• 78-40-0 triethyl phosphate 
• 623-70-1 ethyl (E)-crotonate 
• 1067-87-4 Diethyl allylphosphonate 
• 140-88-5 ethyl acrylate 
• 6065-32-3 4-bromocrotonic ethyl ester 
• 122-52-1 triethyl phosphite 
• 1606-75-3 (2-oxoethyl)phosphonic acid diethyl ester 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 

Downstream Products

• 10236-06-3 5-Methyl-hexa-1,3-dien-1-carbonsaeure-ethylester 
• 1110610-35-9 5-phenyl-hexa-2t,4ξ-dienoic acid ethyl ester 
• 101620-00-2 (2E,4E)-5-(3,5-dimethoxy-4-(2-methoxyethoxy)methoxyphenyl)-2,4-pentadienoic acid ethyl ester 
• 101619-71-0 (2E,4E)-ethyl 5-(3,4-dimethoxyphenyl)penta-2,4-dienoate 
• 74109-37-8 ethyl (2E,4E,6E)-5-methyl-7-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6-hepta-trienoate 
• 202194-34-1 (2E,4E)-5-((1S,3R,4R)-3-Isopropenyl-4-methyl-4-vinyl-cyclohexyl)-hexa-2,4-dienoic acid ethyl ester 
• 233609-19-3 (2E,4E)-(R)-6-Methoxy-8-(4-methoxy-benzyloxy)-octa-2,4-dienoic acid ethyl ester 
• 423772-15-0 (2E,4E,14E,20E)-(7R,8R,9R,10R,13S,17R,19R,23S,24R,25S,26S)-9-(tert-Butyl-dimethyl-silanyloxy)-13,19-dimethoxy-8,10,17,24,26-pentamethyl-7-methylsulfanylmethoxy-23,25-bis-triethylsilanyloxy-27-trityloxy-heptacosa-2,4,14,20-tetraenoic acid ethyl ester 
• 423771-82-8 C₇₆H₁₄₀O₁₄SSi₃ 
• 1026936-75-3 ethyl (E)-5-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]-2,4-pentadienoate 
• 1026499-25-1 (2E,4E)-5-{3-[3-(2,2-Dimethyl-propionylamino)-5-ethyl-2-methoxy-6-methyl-pyridine-4-carbonyl]-phenyl}-penta-2,4-dienoic acid ethyl ester 
• 142247-38-9 4-[1-(tert-butoxycarbonyl)piperidin-4-yl]butanoic acid 
• 183800-91-1 ethyl (2E,4E)-5-[4-(2,2,3,3-tetrafluoropropoxy)phenyl]-2,4-pentadienoate 
• 316362-81-9 ethyl trans-4-(N-benzyl-4'-piperidinyliden)-2-butenoate 

Relevant articles and documents

Stereoselective syntheses of sanshool derivatives

Accessible methods for the syntheses of some representatives of tetradecapentaenoic acid derivatives using organophosphorus reagents and highly stereoselective properties of phosphonate carbanions were developed.

Synthesis of 2,3-dihydroxy-3-(N-substituted carbamoyl)propylphosphonic acid derivatives as hybrid DOXP-fosmidomycin analogues

A six-step synthetic pathway has been established to access a series of racemic 2,3-dihydroxy-3-(N-substituted carbamoyl)propylphosphonic acid derivatives, designed to contain structural features common to both the natural substrate 1-deoxy-D-xylulose 5-p

Total synthesis of Carpatamides A–D

A synthetic strategy was developed for the synthesis of the common core structure of Carpatamides A–D. The total synthesis of Carpatamides A and C was completed in 6 steps and of Carpatamides B and D in 7 steps, by employing the Wittig olefination, olefin