N-(2-(3-(1-cyclohexyl-3-methyl-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide

Base Information

Chemical Name:N-(2-(3-(1-cyclohexyl-3-methyl-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide
CAS No.:1025712-70-2
Molecular Formula:C₂₅H₃₂N₆O₄S
Molecular Weight:512.633
Hs Code.:

Synonyms:N-(2-(3-(1-cyclohexyl-3-methyl-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide

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Chemical Property of N-(2-(3-(1-cyclohexyl-3-methyl-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide

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Technology Process of N-(2-(3-(1-cyclohexyl-3-methyl-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide

There total 10 articles about N-(2-(3-(1-cyclohexyl-3-methyl-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1025713-54-5
1-(2-methanesulfonylamino-benzoyl)-piperidine-3-carboxylic acid (4-carbamoyl-2-cyclohexyl-5-methyl-2H-pyrazol-3-yl)amide

: 1025712-70-2
N-(2-(3-(1-cyclohexyl-3-methyl-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide

Guidance literature:: With sodium hydroxide; In ethanol; water; at 100 ℃; for 18h;

Reference yield:

: 162787-61-3
2-(methylsulfonamido)benzoic acid

: 1025712-70-2
N-(2-(3-(1-cyclohexyl-3-methyl-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,1'-carbonyldiimidazole / dichloromethane / 0.5 h

1.2: 1 h

2.1: lithium hydroxide; water / tetrahydrofuran / 48 h

3.1: thionyl chloride; triethylamine / dichloromethane / 2 h / 0 °C

4.1: triethylamine / dichloromethane / 0.08 h

5.1: sodium hydroxide / ethanol; water / 18 h / 100 °C

With lithium hydroxide; sodium hydroxide; thionyl chloride; water; triethylamine; 1,1'-carbonyldiimidazole; In tetrahydrofuran; ethanol; dichloromethane; water;

Reference yield:

: 30929-57-8
cyclohexylhydrazine dihydrochloride

: 1025712-70-2
N-(2-(3-(1-cyclohexyl-3-methyl-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / ethanol / 16 h / 85 °C

2.1: sulfuric acid / 5.5 h / 0 - 45 °C

2.2: 0 °C

3.1: triethylamine / dichloromethane / 0.08 h

4.1: sodium hydroxide / ethanol; water / 18 h / 100 °C

With sodium hydroxide; sulfuric acid; triethylamine; In ethanol; dichloromethane; water;