5'-O-t-butyldimethylsilyl-3'-carbomethoxymethyl-4-N-benzoyl-2',3'-dideocytidine

Base Information

Chemical Name:5'-O-t-butyldimethylsilyl-3'-carbomethoxymethyl-4-N-benzoyl-2',3'-dideocytidine
CAS No.:161045-35-8
Molecular Formula:C₂₅H₃₅N₃O₆Si
Molecular Weight:501.655
Hs Code.:

Synonyms:5'-O-t-butyldimethylsilyl-3'-carbomethoxymethyl-4-N-benzoyl-2',3'-dideocytidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5'-O-t-butyldimethylsilyl-3'-carbomethoxymethyl-4-N-benzoyl-2',3'-dideocytidine

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Technology Process of 5'-O-t-butyldimethylsilyl-3'-carbomethoxymethyl-4-N-benzoyl-2',3'-dideocytidine

There total 6 articles about 5'-O-t-butyldimethylsilyl-3'-carbomethoxymethyl-4-N-benzoyl-2',3'-dideocytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 98-88-4
benzoyl chloride

: 161045-34-7
5'-O-t-butyldimethylsilyl-3'-carbomethoxymethyl-2',3'-dideocytidine

: 161045-35-8
5'-O-t-butyldimethylsilyl-3'-carbomethoxymethyl-4-N-benzoyl-2',3'-dideocytidine

Guidance literature:: In pyridine; for 2h;
DOI:10.1080/15257779408010666

Reference yield:

: 120232-07-7
5'-O-(tert-butyldimethylsilyl)-3'-C-allyl-2',3'-dideoxyuridine

: 161045-35-8
5'-O-t-butyldimethylsilyl-3'-carbomethoxymethyl-4-N-benzoyl-2',3'-dideocytidine

Guidance literature:: Multi-step reaction with 6 steps

1: 43 percent / OsO₄, aq. NaIO₄ / diethyl ether / 5 h / Ambient temperature

2: 56 percent / pyridinium dichromate / dimethylformamide / 2 h

3: Et₃N, 4-DMAP / 1,2-dichloro-ethane / 4 h

4: NaN₃ / dimethylformamide / Ambient temperature

5: 94 percent / SnCl₂, thiophenol / acetonitrile / 24 h

6: 84 percent / pyridine / 2 h

With dmap; sodium periodate; osmium(VIII) oxide; dipyridinium dichromate; sodium azide; thiophenol; triethylamine; tin(ll) chloride; In pyridine; diethyl ether; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1080/15257779408010666

Reference yield:

: 161045-30-3
5'-O-t-butyldimethylsilyl-3'-(2''-oxoethyl)-2',3'-dideoxyuridine

: 161045-35-8
5'-O-t-butyldimethylsilyl-3'-carbomethoxymethyl-4-N-benzoyl-2',3'-dideocytidine

Guidance literature:: Multi-step reaction with 5 steps

1: 56 percent / pyridinium dichromate / dimethylformamide / 2 h

2: Et₃N, 4-DMAP / 1,2-dichloro-ethane / 4 h

3: NaN₃ / dimethylformamide / Ambient temperature

4: 94 percent / SnCl₂, thiophenol / acetonitrile / 24 h

5: 84 percent / pyridine / 2 h

With dmap; dipyridinium dichromate; sodium azide; thiophenol; triethylamine; tin(ll) chloride; In pyridine; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1080/15257779408010666