(3R,5R)-1-((S)-1-ethoxy-1-oxo-3-phenylpropan-2-yl)-5-isopropyl-2-oxopyrrolidin-3-yl (S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

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Chemical Name:(3R,5R)-1-((S)-1-ethoxy-1-oxo-3-phenylpropan-2-yl)-5-isopropyl-2-oxopyrrolidin-3-yl (S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate
CAS No.:1462969-05-6
Molecular Formula:C₂₈H₃₂F₃NO₆
Molecular Weight:535.56
Hs Code.:

Synonyms:(3R,5R)-1-((S)-1-ethoxy-1-oxo-3-phenylpropan-2-yl)-5-isopropyl-2-oxopyrrolidin-3-yl (S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

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Chemical Property of (3R,5R)-1-((S)-1-ethoxy-1-oxo-3-phenylpropan-2-yl)-5-isopropyl-2-oxopyrrolidin-3-yl (S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

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Technology Process of (3R,5R)-1-((S)-1-ethoxy-1-oxo-3-phenylpropan-2-yl)-5-isopropyl-2-oxopyrrolidin-3-yl (S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

There total 7 articles about (3R,5R)-1-((S)-1-ethoxy-1-oxo-3-phenylpropan-2-yl)-5-isopropyl-2-oxopyrrolidin-3-yl (S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1462969-00-1
ethyl (S)-2-((3R,5R)-3-hydroxy-5-isopropyl-2-oxopyrrolidin-1-yl)-3-phenylpropanoate

: 17257-71-5,20445-31-2,56135-03-6,81655-41-6
(S)-Mosher acid

: 1462969-05-6
(3R,5R)-1-((S)-1-ethoxy-1-oxo-3-phenylpropan-2-yl)-5-isopropyl-2-oxopyrrolidin-3-yl (S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

Guidance literature:: In dichloromethane; at 20 ℃; for 12h;
DOI:10.1016/j.tet.2013.08.084

Reference yield:

: 50547-07-4
ethyl N-hydroxy-L-phenylalaninate

: 1462969-05-6
(3R,5R)-1-((S)-1-ethoxy-1-oxo-3-phenylpropan-2-yl)-5-isopropyl-2-oxopyrrolidin-3-yl (S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

Guidance literature:: Multi-step reaction with 4 steps

1: magnesium sulfate / 4 h / 20 °C

2: toluene / 16 h / 80 °C / Sealed tube

3: hydrogen; 10 wt% Pd(OH)2 on carbon / ethanol / 48 h / 20 °C / 76005.1 Torr

4: dichloromethane / 12 h / 20 °C

With 10 wt% Pd(OH)2 on carbon; hydrogen; magnesium sulfate; In ethanol; dichloromethane; toluene;
DOI:10.1016/j.tet.2013.08.084

Reference yield:

: 1462968-83-7
(S,Z)-N-(1-ethoxy-1-oxo-3-phenylpropan-2-yl)-1-phenylmethanimine oxide

: 1462969-05-6
(3R,5R)-1-((S)-1-ethoxy-1-oxo-3-phenylpropan-2-yl)-5-isopropyl-2-oxopyrrolidin-3-yl (S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide; acetic acid; hydroxylamine hydrochloride / methanol / 16 h / Reflux

2: magnesium sulfate / 4 h / 20 °C

3: toluene / 16 h / 80 °C / Sealed tube

4: hydrogen; 10 wt% Pd(OH)2 on carbon / ethanol / 48 h / 20 °C / 76005.1 Torr

5: dichloromethane / 12 h / 20 °C

With 10 wt% Pd(OH)2 on carbon; hydroxylamine hydrochloride; hydrogen; magnesium sulfate; acetic acid; sodium hydroxide; In methanol; ethanol; dichloromethane; toluene;
DOI:10.1016/j.tet.2013.08.084