ethyl (S)-2-((3R,5R)-3-hydroxy-5-isopropyl-2-oxopyrrolidin-1-yl)-3-phenylpropanoate

Base Information

Chemical Name:ethyl (S)-2-((3R,5R)-3-hydroxy-5-isopropyl-2-oxopyrrolidin-1-yl)-3-phenylpropanoate
CAS No.:1462969-00-1
Molecular Formula:C₁₈H₂₅NO₄
Molecular Weight:319.401
Hs Code.:

Synonyms:ethyl (S)-2-((3R,5R)-3-hydroxy-5-isopropyl-2-oxopyrrolidin-1-yl)-3-phenylpropanoate

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Chemical Property of ethyl (S)-2-((3R,5R)-3-hydroxy-5-isopropyl-2-oxopyrrolidin-1-yl)-3-phenylpropanoate

Chemical Property:

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Technology Process of ethyl (S)-2-((3R,5R)-3-hydroxy-5-isopropyl-2-oxopyrrolidin-1-yl)-3-phenylpropanoate

There total 5 articles about ethyl (S)-2-((3R,5R)-3-hydroxy-5-isopropyl-2-oxopyrrolidin-1-yl)-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3182-93-2
(L)-phenylalanine ethyl ester hydrochloride

: 1462969-00-1
ethyl (S)-2-((3R,5R)-3-hydroxy-5-isopropyl-2-oxopyrrolidin-1-yl)-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: urea hydrogen peroxide adduct; magnesium sulfate; methyltrioxorhenium(VII) / methanol / 7 h / 20 °C

3.1: sodium hydroxide; acetic acid; hydroxylamine hydrochloride / methanol / 16 h / Reflux

4.1: toluene / 16 h / 60 °C / Sealed tube

5.1: hydrogen; 10 wt% Pd(OH)2 on carbon / ethanol / 48 h / 20 °C / 76005.1 Torr

With 10 wt% Pd(OH)2 on carbon; hydroxylamine hydrochloride; hydrogen; urea hydrogen peroxide adduct; methyltrioxorhenium(VII); magnesium sulfate; acetic acid; triethylamine; sodium hydroxide; In methanol; ethanol; dichloromethane; toluene;
DOI:10.1016/j.tet.2013.08.084

Reference yield:

: 78843-66-0,118110-66-0,137967-42-1
(S)-3-Phenyl-2-{[1-phenyl-meth-(E)-ylidene]-amino}-propionic acid ethyl ester

: 1462969-00-1
ethyl (S)-2-((3R,5R)-3-hydroxy-5-isopropyl-2-oxopyrrolidin-1-yl)-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 5 steps

1: urea hydrogen peroxide adduct; magnesium sulfate; methyltrioxorhenium(VII) / methanol / 7 h / 20 °C

2: sodium hydroxide; acetic acid; hydroxylamine hydrochloride / methanol / 16 h / Reflux

3: magnesium sulfate / 4 h / 20 °C

4: toluene / 16 h / 80 °C / Sealed tube

5: hydrogen; 10 wt% Pd(OH)2 on carbon / ethanol / 48 h / 20 °C / 76005.1 Torr

With 10 wt% Pd(OH)2 on carbon; hydroxylamine hydrochloride; hydrogen; urea hydrogen peroxide adduct; methyltrioxorhenium(VII); magnesium sulfate; acetic acid; sodium hydroxide; In methanol; ethanol; toluene;
DOI:10.1016/j.tet.2013.08.084

Reference yield:

: 50547-07-4
ethyl N-hydroxy-L-phenylalaninate

: 1462969-00-1
ethyl (S)-2-((3R,5R)-3-hydroxy-5-isopropyl-2-oxopyrrolidin-1-yl)-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: magnesium sulfate / 4 h / 20 °C

2: toluene / 16 h / 80 °C / Sealed tube

3: hydrogen; 10 wt% Pd(OH)2 on carbon / ethanol / 48 h / 20 °C / 76005.1 Torr

With 10 wt% Pd(OH)2 on carbon; hydrogen; magnesium sulfate; In ethanol; toluene;
DOI:10.1016/j.tet.2013.08.084