12-(benzyloxy)-10-(tert-butoxycarbonyl)-2-methyl-5,10-dihydro-1H-pyrrolo[3',4':4,5]oxocino[2,3-b:6,7,8-c',d']diindole-1,3(2H)-dione

Base Information

Chemical Name:12-(benzyloxy)-10-(tert-butoxycarbonyl)-2-methyl-5,10-dihydro-1H-pyrrolo[3',4':4,5]oxocino[2,3-b:6,7,8-c',d']diindole-1,3(2H)-dione
CAS No.:1287221-12-8
Molecular Formula:C₃₃H₂₇N₃O₆
Molecular Weight:561.594
Hs Code.:

Synonyms:12-(benzyloxy)-10-(tert-butoxycarbonyl)-2-methyl-5,10-dihydro-1H-pyrrolo[3',4':4,5]oxocino[2,3-b:6,7,8-c',d']diindole-1,3(2H)-dione

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Chemical Property of 12-(benzyloxy)-10-(tert-butoxycarbonyl)-2-methyl-5,10-dihydro-1H-pyrrolo[3',4':4,5]oxocino[2,3-b:6,7,8-c',d']diindole-1,3(2H)-dione

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Technology Process of 12-(benzyloxy)-10-(tert-butoxycarbonyl)-2-methyl-5,10-dihydro-1H-pyrrolo[3',4':4,5]oxocino[2,3-b:6,7,8-c',d']diindole-1,3(2H)-dione

There total 4 articles about 12-(benzyloxy)-10-(tert-butoxycarbonyl)-2-methyl-5,10-dihydro-1H-pyrrolo[3',4':4,5]oxocino[2,3-b:6,7,8-c',d']diindole-1,3(2H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1287221-11-7
3-[6-(benzyloxy)-1-(tert-butoxycarbonyl)-1H-indol-3-yl]-4-(4-hydroxy-1H-indol-3-yl)-1-methyl-1H-pyrrole-2,5-dione

: 1287221-12-8
12-(benzyloxy)-10-(tert-butoxycarbonyl)-2-methyl-5,10-dihydro-1H-pyrrolo[3',4':4,5]oxocino[2,3-b:6,7,8-c',d']diindole-1,3(2H)-dione

Guidance literature:: With pyridinium p-toluenesulfonate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In benzene; at 60 ℃; for 0.75h;
DOI:10.1055/s-0030-1258340

Reference yield:

: 1287221-04-8
3-[6-(benzyloxy)-1-(tert-butoxycarbonyl)-1H-indol-3-yl]-1-methyl-4-[4-(tetrahydro-2H-pyran-2-yloxy)-1H-indol-3-yl]-1H-pyrrole-2,5-dione

: 1287221-12-8
12-(benzyloxy)-10-(tert-butoxycarbonyl)-2-methyl-5,10-dihydro-1H-pyrrolo[3',4':4,5]oxocino[2,3-b:6,7,8-c',d']diindole-1,3(2H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1: Amberlyst 15 / methanol / 1 h / Reflux

2: pyridinium p-toluenesulfonate; 2,3-dicyano-5,6-dichloro-p-benzoquinone / benzene / 0.75 h / 60 °C

With pyridinium p-toluenesulfonate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In methanol; benzene;
DOI:10.1055/s-0030-1258340

Reference yield:

: 174402-44-9
tert-butyl 6-(benzyloxy)-3-(4-bromo-1-methyl-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl)-1H-indole-1-carboxylate

: 1287221-12-8
12-(benzyloxy)-10-(tert-butoxycarbonyl)-2-methyl-5,10-dihydro-1H-pyrrolo[3',4':4,5]oxocino[2,3-b:6,7,8-c',d']diindole-1,3(2H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethylmagnesium chloride / tetrahydrofuran / 20 - 50 °C

1.2: 6 h / 50 °C

2.1: Amberlyst 15 / methanol / 1 h / Reflux

3.1: pyridinium p-toluenesulfonate; 2,3-dicyano-5,6-dichloro-p-benzoquinone / benzene / 0.75 h / 60 °C

With ethylmagnesium chloride; pyridinium p-toluenesulfonate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; methanol; benzene;
DOI:10.1055/s-0030-1258340