174402-44-9Relevant academic research and scientific papers
Novel substituted [1,4] benzodioxino[2,3-e] isoindole derivatives, method for preparing and pharmaceutical compositions containing same
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Page/Page column 12, (2010/10/19)
Compounds of formula (I): wherein: A is as defined in the description, Y represents a group selected from an oxygen atom and a methylene group, R2 represents a hydrogen atom and in that case: R3 represents a group selected from a hydrogen atom and the groups linear or branched (C1-C6)alkyl, aryl, aryl-(C1-C6)alkyl (in which the alkyl moiety is linear or branched) and SO2CF3, or R2 and R3 form a bond, R1 represents a group selected from a hydrogen atom and the groups linear or branched (C1-C6)alkyl, aryl and aryl-(C1-C6)alkyl (in which the alkyl moiety is linear or branched) or a linear or branched (C1-C6)alkylene chain, Z1 and Z2 each represent a hydrogen atom or Z1 and Z2, together with the carbon atoms carrying them, form a phenyl group. Medicaments.
Processes for the preparation of indolopyrrolocarbazole derivatives
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Example 12, (2008/06/13)
This invention relates to processes for the preparation of intermediates which are useful in the synthesis of compounds of the general formula or pharmaceutically salts thereof, wherein R1 and R2 each represent an OH group, R1/
Practical synthesis of indolopyrrolocarbazoles
Ohkubo, Mitsuru,Nishimura, Teruyuki,Jona, Hideki,Honma, Teruki,Morishima, Hajime
, p. 8099 - 8112 (2007/10/03)
A practical method for the synthesis of an indolo[2,3-a]pyrrolo[3,4- c]carbazole ring system is described. The method involves two key processes: a coupling reaction between indole and substituted methylmaleimide portions using lithium hexamethyldisilazide (LiHMDS) as a base, and the oxidative cyclization of bisindolylmaleimide with palladium (II) chloride. We applied this method to the synthesis of arcyriaflavin B (5), C (6) and D (7).
