5'-O--2'-deoxyuridine-5-propionic acid p-nitrophenylester

Base Information

• Chemical Name: 5'-O--2'-deoxyuridine-5-propionic acid p-nitrophenylester
• CAS No.: 128870-22-4
• Molecular Formula: C₃₉H₃₇N₃O₁₁
• Molecular Weight: 723.736
• Mol file: 128870-22-4.mol

Synonyms:5'-O--2'-deoxyuridine-5-propionic acid p-nitrophenylester

Chemical Property of 5'-O--2'-deoxyuridine-5-propionic acid p-nitrophenylester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 5'-O--2'-deoxyuridine-5-propionic acid p-nitrophenylester

There total 3 articles about 5'-O--2'-deoxyuridine-5-propionic acid p-nitrophenylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + 2'-Deoxyuridine-5-propionic acid p-nitrophenylester (128870-21-3) → 5'-O--2'-deoxyuridine-5-propionic acid p-nitrophenylester (128870-22-4)

Guidance literature:

With pyridine; for 4h;

DOI:10.1021/jo00304a026

Reference yield:

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) → 5'-O--2'-deoxyuridine-5-propionic acid p-nitrophenylester (128870-22-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / DCC / dimethylformamide / 1) 0 deg C, 30 min 2) r.t., 6h

2: 70 percent / pyridine / 4 h

With pyridine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;

DOI:10.1021/jo00304a026

Reference yield:

5-(2-carbethoxyethyl)-2'-deoxyuridine (128870-20-2) → 5'-O--2'-deoxyuridine-5-propionic acid p-nitrophenylester (128870-22-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / DCC / dimethylformamide / 1) 0 deg C, 30 min 2) r.t., 6h

2: 70 percent / pyridine / 4 h

With pyridine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;

DOI:10.1021/jo00304a026

upstream raw materials:

4,4'-dimethoxytrityl chloride

2'-Deoxyuridine-5-propionic acid p-nitrophenylester

4-nitro-phenol

5-(2-carbethoxyethyl)-2'-deoxyuridine

Downstream raw materials:

5'-O--5-<3-<<2-<<<1--1H-imidazol-4-yl>acetyl>amino>ethyl>amino>-3-oxopropyl>-2'-deoxyuridine