2-{5-[⁽³⁵⁾-3-amino-4-phenylbut-1-yn-1-yl]pyridin-3-yl}-8,9-dimethoxybenzo[c][2,7]naphthyridin-4-amine

Base Information

• Chemical Name: 2-{5-[⁽³⁵⁾-3-amino-4-phenylbut-1-yn-1-yl]pyridin-3-yl}-8,9-dimethoxybenzo[c][2,7]naphthyridin-4-amine
• CAS No.: 1055964-36-7
• Molecular Formula: C₂₉H₂₅N₅O₂
• Molecular Weight: 475.55

Synonyms:2-{5-[⁽³⁵⁾-3-amino-4-phenylbut-1-yn-1-yl]pyridin-3-yl}-8,9-dimethoxybenzo[c][2,7]naphthyridin-4-amine

Chemical Property of 2-{5-[⁽³⁵⁾-3-amino-4-phenylbut-1-yn-1-yl]pyridin-3-yl}-8,9-dimethoxybenzo[c][2,7]naphthyridin-4-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{5-[⁽³⁵⁾-3-amino-4-phenylbut-1-yn-1-yl]pyridin-3-yl}-8,9-dimethoxybenzo[c][2,7]naphthyridin-4-amine

There total 10 articles about 2-{5-[⁽³⁵⁾-3-amino-4-phenylbut-1-yn-1-yl]pyridin-3-yl}-8,9-dimethoxybenzo[c][2,7]naphthyridin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.9%

{3-[5-(4-amino-8,9-dimethoxy-benzo[c][2,7]naphthyridin-2-yl)-pyridin-3-yl]-1-benzyl-prop-2-ynyl}-carbamic acid tert-butyl ester (1055969-37-3) → 2-{5-[(35)-3-amino-4-phenylbut-1-yn-1-yl]pyridin-3-yl}-8,9-dimethoxybenzo[c][2,7]naphthyridin-4-amine (1055964-36-7)

Guidance literature:

{3-[5-(4-amino-8,9-dimethoxy-benzo[c][2,7]naphthyridin-2-yl)-pyridin-3-yl]-1-benzyl-prop-2-ynyl}-carbamic acid tert-butyl ester; With hydrogenchloride; In tetrahydrofuran; water; at 65 ℃; for 2h;

With sodium hydroxide; In tetrahydrofuran; water;

Reference yield:

2-amino-4,5-dimethoxyacetophenone (4101-30-8) → 2-{5-[(35)-3-amino-4-phenylbut-1-yn-1-yl]pyridin-3-yl}-8,9-dimethoxybenzo[c][2,7]naphthyridin-4-amine (1055964-36-7)

Guidance literature:

Multi-step reaction with 7 steps

1.1: ammonium acetate / 10 h / 165 °C / Heating / reflux

2.1: trichlorophosphate / 12 h / Heating / reflux

3.1: potassium carbonate / tetrahydrofuran; water / 6 h

3.2: 10 h / 2585.81 Torr

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 18 h / -60 - 15 °C

4.2: 1 h

5.1: ammonium acetate / phenol / 2 h / 100 °C

6.1: piperidine / copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine / 1 h / Heating / reflux

7.1: hydrogenchloride / tetrahydrofuran; water / 2 h / 65 °C

With piperidine; hydrogenchloride; ammonium acetate; potassium carbonate; lithium hexamethyldisilazane; trichlorophosphate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine; In tetrahydrofuran; water; phenol;

Reference yield:

6,7-dimethoxy-4-methyl-3-cyanoquinoline (1055962-40-7) → 2-{5-[(35)-3-amino-4-phenylbut-1-yn-1-yl]pyridin-3-yl}-8,9-dimethoxybenzo[c][2,7]naphthyridin-4-amine (1055964-36-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 18 h / -60 - 15 °C

1.2: 1 h

2.1: ammonium acetate / phenol / 2 h / 100 °C

3.1: piperidine / copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine / 1 h / Heating / reflux

4.1: hydrogenchloride / tetrahydrofuran; water / 2 h / 65 °C

With piperidine; hydrogenchloride; ammonium acetate; lithium hexamethyldisilazane; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine; In tetrahydrofuran; water; phenol;

upstream raw materials:

{3-[5-(4-amino-8,9-dimethoxy-benzo[c][2,7]naphthyridin-2-yl)-pyridin-3-yl]-1-benzyl-prop-2-ynyl}-carbamic acid tert-butyl ester

6,7-dimethoxy-4-methyl-3-cyanoquinoline

6,7-dimethoxy-4-methyl-2-oxo-1,2-dihydro-quinoline-3-carbonitrile

C₁₉H₁₄BrN₃O₃

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1055964-36-7 2-{5-[⁽³⁵⁾-3-amino-4-phenylbut-1-yn-1-yl]pyridin-3-yl}-8,9-dimethoxybenzo[c][2,7]naphthyridin-4-amine

Send

Send

Metric Ton KG G Pound L ML

Send

Send