(3RS,9bRS,12aRS)-12-(4-chlorophenyl)-1,4,5,12a-tetrahydro-7,8-dimethoxy-3-methyl-2H-isoxazolo<5',4':2,3>pyrrolo<2,1-a>isoquinolinium iodide

Base Information

• Chemical Name: (3RS,9bRS,12aRS)-12-(4-chlorophenyl)-1,4,5,12a-tetrahydro-7,8-dimethoxy-3-methyl-2H-isoxazolo<5',4':2,3>pyrrolo<2,1-a>isoquinolinium iodide
• CAS No.: 133964-03-1
• Molecular Formula: C₂₂H₂₄ClN₂O₃*I
• Molecular Weight: 526.802
• Mol file: 133964-03-1.mol

Synonyms:(3RS,9bRS,12aRS)-12-(4-chlorophenyl)-1,4,5,12a-tetrahydro-7,8-dimethoxy-3-methyl-2H-isoxazolo<5',4':2,3>pyrrolo<2,1-a>isoquinolinium iodide

Chemical Property of (3RS,9bRS,12aRS)-12-(4-chlorophenyl)-1,4,5,12a-tetrahydro-7,8-dimethoxy-3-methyl-2H-isoxazolo<5',4':2,3>pyrrolo<2,1-a>isoquinolinium iodide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3RS,9bRS,12aRS)-12-(4-chlorophenyl)-1,4,5,12a-tetrahydro-7,8-dimethoxy-3-methyl-2H-isoxazolo<5',4':2,3>pyrrolo<2,1-a>isoquinolinium iodide

There total 3 articles about (3RS,9bRS,12aRS)-12-(4-chlorophenyl)-1,4,5,12a-tetrahydro-7,8-dimethoxy-3-methyl-2H-isoxazolo<5',4':2,3>pyrrolo<2,1-a>isoquinolinium iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(9bRS,12aRS)-12-(4-chlorophenyl)-1,4,5,12a-tetrahydro-7,8-dimethoxy-2H-isoxazolo<5',4':2,3>pyrrolo<2,1-a>isoquinoline (133964-02-0) + methyl iodide (74-88-4) → (3RS,9bRS,12aRS)-12-(4-chlorophenyl)-1,4,5,12a-tetrahydro-7,8-dimethoxy-3-methyl-2H-isoxazolo<5',4':2,3>pyrrolo<2,1-a>isoquinolinium iodide (133964-03-1)

Guidance literature:

In neat (no solvent); Heating;

DOI:10.1016/S0040-4039(00)99495-4

Reference yield:

8,9-dimethoxy-2,3,5,6-tetrahydro-1H-pyrrolo[2,1-a]isoquinolinium; bromide (123420-50-8) → (3RS,9bRS,12aRS)-12-(4-chlorophenyl)-1,4,5,12a-tetrahydro-7,8-dimethoxy-3-methyl-2H-isoxazolo<5',4':2,3>pyrrolo<2,1-a>isoquinolinium iodide (133964-03-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / Et₃N / CHCl₃ / 1) ice bath, 2) 25 deg C

2: 96 percent / Heating

With triethylamine; In chloroform;

DOI:10.1021/jo00015a025

Reference yield:

4-chlorobenzohydroximoyl chloride (28123-63-9) → (3RS,9bRS,12aRS)-12-(4-chlorophenyl)-1,4,5,12a-tetrahydro-7,8-dimethoxy-3-methyl-2H-isoxazolo<5',4':2,3>pyrrolo<2,1-a>isoquinolinium iodide (133964-03-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / Et₃N / CHCl₃ / 1) ice bath, 2) 25 deg C

2: 96 percent / Heating

With triethylamine; In chloroform;

DOI:10.1021/jo00015a025

upstream raw materials:

(9bRS,12aRS)-12-(4-chlorophenyl)-1,4,5,12a-tetrahydro-7,8-dimethoxy-2H-isoxazolo<5',4':2,3>pyrrolo<2,1-a>isoquinoline

methyl iodide

8,9-dimethoxy-2,3,5,6-tetrahydro-1H-pyrrolo[2,1-a]isoquinolinium; bromide

4-chlorobenzohydroximoyl chloride

Downstream raw materials:

3-(4-chlorophenyl)-5,6,7,8-tetrahydro-10,11-dimethoxy-6-methyl-4H-isoxazolo<4,5-g><3>benzazonine