1-(6,8-dichloro-2-phenyl-1,3-dioxa-4-aza-cyclopenta[b]naphthalen-9-yl)-3-ethyl-1-methyl-urea

Base Information

Chemical Name:1-(6,8-dichloro-2-phenyl-1,3-dioxa-4-aza-cyclopenta[b]naphthalen-9-yl)-3-ethyl-1-methyl-urea
CAS No.:185804-89-1
Molecular Formula:C₂₀H₁₇Cl₂N₃O₃
Molecular Weight:418.279
Hs Code.:

1-(6,8-dichloro-2-phenyl-1,3-dioxa-4-aza-cyclopenta[<i>b</i>]naphthalen-9-yl)-3-ethyl-1-methyl-urea

Synonyms:1-(6,8-dichloro-2-phenyl-1,3-dioxa-4-aza-cyclopenta[b]naphthalen-9-yl)-3-ethyl-1-methyl-urea

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Chemical Property of 1-(6,8-dichloro-2-phenyl-1,3-dioxa-4-aza-cyclopenta[b]naphthalen-9-yl)-3-ethyl-1-methyl-urea

Chemical Property:

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Technology Process of 1-(6,8-dichloro-2-phenyl-1,3-dioxa-4-aza-cyclopenta[b]naphthalen-9-yl)-3-ethyl-1-methyl-urea

There total 5 articles about 1-(6,8-dichloro-2-phenyl-1,3-dioxa-4-aza-cyclopenta[b]naphthalen-9-yl)-3-ethyl-1-methyl-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 185804-87-9
1-(6,8-dichloro-2-phenyl-1,3-dioxa-4-aza-cyclopenta[b]naphthalen-9-yl)-3-ethyl-urea

: 74-88-4
methyl iodide

: 185804-89-1
1-(6,8-dichloro-2-phenyl-1,3-dioxa-4-aza-cyclopenta[b]naphthalen-9-yl)-3-ethyl-1-methyl-urea

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 185804-85-7
6,8-dichloro-2-phenyl-1,3-dioxa-4-aza-cyclopenta[b]naphthalene-9-carboxylic acid

: 185804-89-1
1-(6,8-dichloro-2-phenyl-1,3-dioxa-4-aza-cyclopenta[b]naphthalen-9-yl)-3-ethyl-1-methyl-urea

Guidance literature:: Multi-step reaction with 2 steps

1: 29 percent / Et₃N; (PhO)2PON₃ / toluene / 20 - 100 °C

2: 87 percent / NaH / dimethylformamide / 20 °C

With diphenyl phosphoryl azide; sodium hydride; triethylamine; In N,N-dimethyl-formamide; toluene; 1: Addition / 1: Addition / 2: Methylation;

Reference yield:

: 6,8-dichloro-2-phenyl-1,3-dioxa-4-aza-cyclopenta[b]naphthalene-9-carboxylic acid methyl ester

: 185804-89-1
1-(6,8-dichloro-2-phenyl-1,3-dioxa-4-aza-cyclopenta[b]naphthalen-9-yl)-3-ethyl-1-methyl-urea

Guidance literature:: Multi-step reaction with 3 steps

1: 69 percent / lithium iodide, pyridine / 100 °C

2: 29 percent / Et₃N; (PhO)2PON₃ / toluene / 20 - 100 °C

3: 87 percent / NaH / dimethylformamide / 20 °C

With pyridine; diphenyl phosphoryl azide; sodium hydride; triethylamine; lithium iodide; In N,N-dimethyl-formamide; toluene; 1: ester cleavage / 2: Addition / 2: Addition / 3: Methylation;