[5,6-dichloro-2-(3,4-dimethoxyphenyl)-1H-benzimidazol-1-yl]-acetic acid hydrazide

Base Information

• Chemical Name: [5,6-dichloro-2-(3,4-dimethoxyphenyl)-1H-benzimidazol-1-yl]-acetic acid hydrazide
• CAS No.: 1002322-40-8
• Molecular Formula: C₁₇H₁₆Cl₂N₄O₃
• Molecular Weight: 395.245
• Mol file: 1002322-40-8.mol

Synonyms:[5,6-dichloro-2-(3,4-dimethoxyphenyl)-1H-benzimidazol-1-yl]-acetic acid hydrazide

Chemical Property of [5,6-dichloro-2-(3,4-dimethoxyphenyl)-1H-benzimidazol-1-yl]-acetic acid hydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [5,6-dichloro-2-(3,4-dimethoxyphenyl)-1H-benzimidazol-1-yl]-acetic acid hydrazide

There total 4 articles about [5,6-dichloro-2-(3,4-dimethoxyphenyl)-1H-benzimidazol-1-yl]-acetic acid hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

[5,6-dichloro-2-(3,4-dimethoxyphenyl)-1H-benzimidazol-1-yl]-acetic acid ethyl ester (1002322-39-5) → [5,6-dichloro-2-(3,4-dimethoxyphenyl)-1H-benzimidazol-1-yl]-acetic acid hydrazide (1002322-40-8)

Guidance literature:

With hydrazine hydrate; In ethanol; for 4h; Heating;

DOI:10.1016/j.bmc.2008.02.077

Reference yield:

4,5-Dichloro-1,2-phenylenediamine (5348-42-5) → [5,6-dichloro-2-(3,4-dimethoxyphenyl)-1H-benzimidazol-1-yl]-acetic acid hydrazide (1002322-40-8)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium metabisulfite

2: potassium hydroxide / dimethyl sulfoxide

3: hydrazine / ethanol / 4 h / Reflux

With sodium metabisulfite; potassium hydroxide; hydrazine; In ethanol; dimethyl sulfoxide;

DOI:10.1002/ardp.201300324

Reference yield:

3,4-dimethoxy-benzaldehyde (120-14-9) → [5,6-dichloro-2-(3,4-dimethoxyphenyl)-1H-benzimidazol-1-yl]-acetic acid hydrazide (1002322-40-8)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium metabisulfite

2: potassium hydroxide / dimethyl sulfoxide

3: hydrazine / ethanol / 4 h / Reflux

With sodium metabisulfite; potassium hydroxide; hydrazine; In ethanol; dimethyl sulfoxide;

DOI:10.1002/ardp.201300324

upstream raw materials:

[5,6-dichloro-2-(3,4-dimethoxyphenyl)-1H-benzimidazol-1-yl]-acetic acid ethyl ester

4,5-Dichloro-1,2-phenylenediamine

3,4-dimethoxy-benzaldehyde

5,6-dichloro-2-[(3,4-dimethoxy)phenyl]-1H-benzimidazole

Downstream raw materials:

C₁₉H₁₉Cl₂N₅O₃S

C₁₈H₁₄Cl₂N₄O₃S