N-[[1-amino-7-(3-fluorophenyl)-4-isoquinolyl]methyl]cyclopropanesulfonamide

Base Information

• Chemical Name: N-[[1-amino-7-(3-fluorophenyl)-4-isoquinolyl]methyl]cyclopropanesulfonamide
• CAS No.: 1449278-06-1
• Molecular Formula: C₁₉H₁₈FN₃O₂S
• Molecular Weight: 371.435
• Mol file: 1449278-06-1.mol

Synonyms:N-[[1-amino-7-(3-fluorophenyl)-4-isoquinolyl]methyl]cyclopropanesulfonamide

Chemical Property of N-[[1-amino-7-(3-fluorophenyl)-4-isoquinolyl]methyl]cyclopropanesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[[1-amino-7-(3-fluorophenyl)-4-isoquinolyl]methyl]cyclopropanesulfonamide

There total 4 articles about N-[[1-amino-7-(3-fluorophenyl)-4-isoquinolyl]methyl]cyclopropanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

cyclopropanesulfonic acid (21297-68-7) + 4-(aminomethyl)-7-(3-fluorophenyl)isoquinolin-1-amine (1449276-78-1) → N-[[1-amino-7-(3-fluorophenyl)-4-isoquinolyl]methyl]cyclopropanesulfonamide (1449278-06-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Inert atmosphere;

Reference yield:

1-amino-7-(3-fluorophenyl)isoquinoline-4-carboxamide (1449277-39-7) → N-[[1-amino-7-(3-fluorophenyl)-4-isoquinolyl]methyl]cyclopropanesulfonamide (1449278-06-1)

Guidance literature:

Multi-step reaction with 3 steps

1: trichlorophosphate / Inert atmosphere; Reflux

2: ammonium hydroxide; hydrogen / methanol / 50 °C / 2585.81 Torr

3: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

With ammonium hydroxide; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; trichlorophosphate; In methanol; N,N-dimethyl-formamide;

Reference yield:

1-amino-7-(3-fluorophenyl)isoquinoline-4-carboxylic acid (1449277-95-5) → N-[[1-amino-7-(3-fluorophenyl)-4-isoquinolyl]methyl]cyclopropanesulfonamide (1449278-06-1)

Guidance literature:

Multi-step reaction with 4 steps

1: ammonium chloride; HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 40 - 50 °C / Inert atmosphere

2: trichlorophosphate / Inert atmosphere; Reflux

3: ammonium hydroxide; hydrogen / methanol / 50 °C / 2585.81 Torr

4: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

With ammonium hydroxide; hydrogen; ammonium chloride; N-ethyl-N,N-diisopropylamine; HATU; trichlorophosphate; In methanol; N,N-dimethyl-formamide;

upstream raw materials:

1-amino-7-(3-fluorophenyl)isoquinoline-4-carboxamide

1-amino-7-(3-fluorophenyl)isoquinoline-4-carboxylic acid

cyclopropanesulfonic acid

4-(aminomethyl)-7-(3-fluorophenyl)isoquinolin-1-amine