21297-68-7 Usage
Description
Cyclopropanesulfonic acid, with the chemical formula C3H6O3S, is an organic compound that exists as a colorless liquid. It possesses a strong sulfonic acid characteristic, making it highly reactive and a potent acid. This reactivity positions it as a significant intermediate in the synthesis of various chemical products.
Uses
Used in Organic Synthesis:
Cyclopropanesulfonic acid is utilized as a reagent in organic synthesis, particularly for the preparation of cycloalkane derivatives. Its strong acidic properties and reactivity make it a valuable component in creating complex organic molecules.
Used as a Catalyst in Chemical Reactions:
In the realm of catalysis, cyclopropanesulfonic acid serves as a catalyst in various chemical reactions. It plays a crucial role in the Friedel-Crafts acylation and alkylation reactions, which are fundamental processes in organic chemistry for the formation of carbon-carbon and carbon-heteroatom bonds.
Used in Pharmaceutical Production:
Due to its reactivity and ability to form diverse chemical intermediates, cyclopropanesulfonic acid is an important intermediate in the production of pharmaceuticals. It aids in the synthesis of a wide range of medicinal compounds, contributing to the development of new drugs and therapies.
Used in Agrochemical Production:
Similarly, in the agrochemical industry, cyclopropanesulfonic acid is employed as an intermediate for the synthesis of various agrochemicals. Its role in creating specific chemical structures is vital for the development of effective pesticides and other agricultural chemicals.
Used in Specialty Chemicals Production:
Beyond pharmaceuticals and agrochemicals, cyclopropanesulfonic acid is also used in the production of specialty chemicals. Its versatility and reactivity make it suitable for creating unique chemical entities for specific industrial applications.
Safety Precautions:
Given its corrosive and toxic nature, it is imperative to handle and store cyclopropanesulfonic acid with extreme caution. Proper safety measures should be implemented to prevent accidents and ensure the well-being of individuals involved in its use and production.
Check Digit Verification of cas no
The CAS Registry Mumber 21297-68-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,2,9 and 7 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 21297-68:
(7*2)+(6*1)+(5*2)+(4*9)+(3*7)+(2*6)+(1*8)=107
107 % 10 = 7
So 21297-68-7 is a valid CAS Registry Number.
InChI:InChI=1/C3H6O3S/c4-7(5,6)3-1-2-3/h3H,1-2H2,(H,4,5,6)
21297-68-7Relevant articles and documents
Grignon-Dubois et al.
, p. 1197 (1976)
Cyclopropanesulfonyl Chloride: Its Mechanism of Hydrolysis and Reactions with Tertiary Amines in Organic Media
King, James F.,Lam, Joe Y. L.,Ferrazzi, Gabriele
, p. 1128 - 1135 (2007/10/02)
Cyclopropanesulfonyl chloride (1) has been synthesized and its reactions examined to see if the three-membered ring leads to unusual reactions in either 1 or the corresponding sulfene, cyclopropanethione S,S-dioxide (2). pH-rate profiles, primary kinetic isotope effects (KIE's), and pH-product ratio experiments are in full agreement with mechanisms of hydrolysis of 1 like those of a simple alkanesulfonyl chlorides (J.Am.Chem.Soc.1992,114,1743-1749), specifically, (a) below pH 7.2 by SN2-S reaction with water and (b) above pH 7.3, elimination by hydroxide to form the sulfene (2) which is trapped by (i) water below pH 12.0 and (ii) hydroxide above pH 12.0.The products of the reaction of cyclopropanesulfonyl-1-d chloride (9) with triethylamine and 2-propanol in dichloromethane indicate that most of the reaction goes via 2; the analogous reaction with trimethylamine apparently proceeds by a direct formation of the sulfonylammonium chloride (14) which then yields the α-deuterated N,N-dimethyl sulfonamide (12, R=Me).The evident sulfene formation processes in the reaction of triethylamine with ethenesulfonyl, 2-propanesulfonyl, and cyclopropanesulfonyl chlorides show very low primary KIE's (1.5), pointing to highly product-like transition states.Reaction of 1 with an enamine (1-pyrrolidino-2-methylpropene, 20) in the presence of a base in either water or dichloromethane gave cyclopropanesulfonpyrrolidide (23) and an aldehyde adduct (24), but no four-membered cycloadduct (21).
