N-((t-butyloxy)carbonyl)-N'-(3,4,5-trimethoxybenzyl)-N-1-(4-chlorobenzhydryl)piperazine iminodiacetic acid diamide

Base Information

Chemical Name:N-((t-butyloxy)carbonyl)-N'-(3,4,5-trimethoxybenzyl)-N-1-(4-chlorobenzhydryl)piperazine iminodiacetic acid diamide
CAS No.:737828-56-7
Molecular Formula:C₃₆H₄₅ClN₄O₇
Molecular Weight:681.229
Hs Code.:

Synonyms:N-((t-butyloxy)carbonyl)-N'-(3,4,5-trimethoxybenzyl)-N-1-(4-chlorobenzhydryl)piperazine iminodiacetic acid diamide

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Chemical Property of N-((t-butyloxy)carbonyl)-N'-(3,4,5-trimethoxybenzyl)-N-1-(4-chlorobenzhydryl)piperazine iminodiacetic acid diamide

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Technology Process of N-((t-butyloxy)carbonyl)-N'-(3,4,5-trimethoxybenzyl)-N-1-(4-chlorobenzhydryl)piperazine iminodiacetic acid diamide

There total 3 articles about N-((t-butyloxy)carbonyl)-N'-(3,4,5-trimethoxybenzyl)-N-1-(4-chlorobenzhydryl)piperazine iminodiacetic acid diamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

: 188625-16-3
N-((tert-butyloxy)carbonyl)-N'-(3,4,5-trimethoxybenzyl)iminodiacetic acid monoamide

: 737828-56-7
N-((t-butyloxy)carbonyl)-N'-(3,4,5-trimethoxybenzyl)-N-1-(4-chlorobenzhydryl)piperazine iminodiacetic acid diamide

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1016/j.bmc.2004.04.031

Reference yield:

: 56074-21-6
N-((tert-butyloxy)carbonyl)iminodiacetic acid anhydride

: 737828-56-7
N-((t-butyloxy)carbonyl)-N'-(3,4,5-trimethoxybenzyl)-N-1-(4-chlorobenzhydryl)piperazine iminodiacetic acid diamide

Guidance literature:: Multi-step reaction with 2 steps

1: 0.23 g / dimethylformamide / 20 h

2: 81 percent / PyBOP; i-Pr₂NEt / dimethylformamide / 16 h / 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2004.04.031

Reference yield:

: 56074-20-5
N-((tert-butyloxy)carbonyl)iminodiacetic acid

: 737828-56-7
N-((t-butyloxy)carbonyl)-N'-(3,4,5-trimethoxybenzyl)-N-1-(4-chlorobenzhydryl)piperazine iminodiacetic acid diamide

Guidance literature:: Multi-step reaction with 3 steps

1: EDCI / dimethylformamide / 1 h / 20 °C

2: 0.23 g / dimethylformamide / 20 h

3: 81 percent / PyBOP; i-Pr₂NEt / dimethylformamide / 16 h / 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2004.04.031