3,4-dihydro-4-oxo-3-[4-(trifluoromethyl)phenyl]-2-quinazolinecarbothioic acid S-p-tolyl ester

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Chemical Name:3,4-dihydro-4-oxo-3-[4-(trifluoromethyl)phenyl]-2-quinazolinecarbothioic acid S-p-tolyl ester
CAS No.:852534-84-0
Molecular Formula:C₂₃H₁₅F₃N₂O₂S
Molecular Weight:440.446
Hs Code.:

Synonyms:3,4-dihydro-4-oxo-3-[4-(trifluoromethyl)phenyl]-2-quinazolinecarbothioic acid S-p-tolyl ester

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Chemical Property of 3,4-dihydro-4-oxo-3-[4-(trifluoromethyl)phenyl]-2-quinazolinecarbothioic acid S-p-tolyl ester

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Technology Process of 3,4-dihydro-4-oxo-3-[4-(trifluoromethyl)phenyl]-2-quinazolinecarbothioic acid S-p-tolyl ester

There total 3 articles about 3,4-dihydro-4-oxo-3-[4-(trifluoromethyl)phenyl]-2-quinazolinecarbothioic acid S-p-tolyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 106-45-6
para-thiocresol

: 361180-29-2
4-oxo-3-(4-trifluoromethyl-phenyl)-3,4-dihydro-quinazoline-2-carboxylic acid ethyl ester

: 852534-84-0
3,4-dihydro-4-oxo-3-[4-(trifluoromethyl)phenyl]-2-quinazolinecarbothioic acid S-p-tolyl ester

Guidance literature:: With trimethylaluminum; In hexane; dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.tet.2005.02.038

Reference yield:

: 852534-79-3
N-[2-(4-trifluoromethyl-phenylcarbamoyl)-phenyl]-oxalamic acid ethyl ester

: 852534-84-0
3,4-dihydro-4-oxo-3-[4-(trifluoromethyl)phenyl]-2-quinazolinecarbothioic acid S-p-tolyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / Et₃N; trimethylsilyl chloride / 1,2-dichloro-ethane / 1.5 h / 80 °C

2: 60 percent / AlMe₃ / CH₂Cl₂; hexane / 0 - 20 °C

With chloro-trimethyl-silane; trimethylaluminum; triethylamine; In hexane; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/j.tet.2005.02.038

Reference yield:

: 263559-08-6
2-amino-N-(4-(trifluoromethyl)phenyl)benzamide

: 852534-84-0
3,4-dihydro-4-oxo-3-[4-(trifluoromethyl)phenyl]-2-quinazolinecarbothioic acid S-p-tolyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / pyridine / tetrahydrofuran / 0.25 h / 0 °C

2: 94 percent / Et₃N; trimethylsilyl chloride / 1,2-dichloro-ethane / 1.5 h / 80 °C

3: 60 percent / AlMe₃ / CH₂Cl₂; hexane / 0 - 20 °C

With pyridine; chloro-trimethyl-silane; trimethylaluminum; triethylamine; In tetrahydrofuran; hexane; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/j.tet.2005.02.038