4-(2-cyanoethyl)-2-isobutylphenyl trifluoromethanesulfonate

Base Information

• Chemical Name: 4-(2-cyanoethyl)-2-isobutylphenyl trifluoromethanesulfonate
• CAS No.: 434300-54-6
• Molecular Formula: C₁₄H₁₆F₃NO₃S
• Molecular Weight: 335.347
• Mol file: 434300-54-6.mol

Synonyms:4-(2-cyanoethyl)-2-isobutylphenyl trifluoromethanesulfonate

Chemical Property of 4-(2-cyanoethyl)-2-isobutylphenyl trifluoromethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-cyanoethyl)-2-isobutylphenyl trifluoromethanesulfonate

There total 6 articles about 4-(2-cyanoethyl)-2-isobutylphenyl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

3-(4-hydroxy-3-isobutylphenyl)propanenitrile (475272-06-1) → 4-(2-cyanoethyl)-2-isobutylphenyl trifluoromethanesulfonate (434300-54-6)

Guidance literature:

With trifluoromethylsulfonic anhydride; In pyridine; water;

Reference yield: 90.0%

3-(4-hydroxy-3-isobutylphenyl)propanenitrile (475272-06-1) + trifluoromethylsulfonic anhydride (358-23-6) → 4-(2-cyanoethyl)-2-isobutylphenyl trifluoromethanesulfonate (434300-54-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1021/ja050122x

Reference yield:

4-iodo-2-isobutylanisole (475272-03-8) → 4-(2-cyanoethyl)-2-isobutylphenyl trifluoromethanesulfonate (434300-54-6)

Guidance literature:

Multi-step reaction with 4 steps

1: Bu₄NCl; NaHCO₃ / Pd(OAc)2 / dimethylformamide / 40 °C

2: Mg / methanol / 20 °C

3: BBr₃ / CH₂Cl₂ / 20 °C

4: pyridine / 20 °C

With pyridine; tetrabutyl-ammonium chloride; boron tribromide; sodium hydrogencarbonate; magnesium; palladium diacetate; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/anie.200462316

upstream raw materials:

3-(4-hydroxy-3-isobutylphenyl)propanenitrile

trifluoromethylsulfonic anhydride

4-iodo-2-isobutylanisole

3-(3-isobutyl-4-methoxyphenyl)propanenitrile

Downstream raw materials:

3-[3-isobutyl-4-(1-isobutyl-7-methoxy-6-methyl-indan-4-yl)-phenyl]-propionitrile

3-(3'-Benzyl-4-(carboxymethoxy)-2,3-diisobutyl-1,1':4',1-terphenyl-4-yl)propanoic acid

3-(3,2''-diisobutyl-4-methoxycarbonylmethoxy-2'-naphthalen-1-ylmethyl-[1,1':4',1'']-terphenyl-4''-yl)propionic acid methyl ester

3-(2',2''-diisobutyl-4-methoxycarbonylmethoxy-3-naphthalen-1-ylmethyl-[1,1':4',1'']-terphenyl-4''-yl)propionic acid methyl ester