3-[3-isobutyl-4-(1-isobutyl-7-methoxy-6-methyl-indan-4-yl)-phenyl]-propionitrile

Base Information

Chemical Name:3-[3-isobutyl-4-(1-isobutyl-7-methoxy-6-methyl-indan-4-yl)-phenyl]-propionitrile
CAS No.:888328-91-4
Molecular Formula:C₂₈H₃₇NO
Molecular Weight:403.608
Hs Code.:

Synonyms:3-[3-isobutyl-4-(1-isobutyl-7-methoxy-6-methyl-indan-4-yl)-phenyl]-propionitrile

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Chemical Property of 3-[3-isobutyl-4-(1-isobutyl-7-methoxy-6-methyl-indan-4-yl)-phenyl]-propionitrile

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Technology Process of 3-[3-isobutyl-4-(1-isobutyl-7-methoxy-6-methyl-indan-4-yl)-phenyl]-propionitrile

There total 7 articles about 3-[3-isobutyl-4-(1-isobutyl-7-methoxy-6-methyl-indan-4-yl)-phenyl]-propionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₅H₂₃BO₃

: trifluoro-acetic acid 4-(2-cyano-ethyl)-2-isobutyl-phenyl ester

: 888328-91-4
3-[3-isobutyl-4-(1-isobutyl-7-methoxy-6-methyl-indan-4-yl)-phenyl]-propionitrile

Guidance literature:: With caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; at 120 ℃; for 2h;
DOI:10.1021/ol052956q

Reference yield:

: 888328-89-0
1-isobutyl-7-methoxy-6-methyl-indan

: 888328-91-4
3-[3-isobutyl-4-(1-isobutyl-7-methoxy-6-methyl-indan-4-yl)-phenyl]-propionitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: 90 percent / acetic acid; NBS / 2 h / 85 °C

2.1: n-BuLi / tetrahydrofuran / 0.5 h / -75 °C

2.2: tetrahydrofuran / 24 h / 20 °C

2.3: NaOH / H₂O / 1 h

3.1: 0.30 g / Cs₂CO₃ / Pd(PPh₃)4 / dimethylformamide; H₂O / 2 h / 120 °C

With N-Bromosuccinimide; n-butyllithium; caesium carbonate; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; N,N-dimethyl-formamide; 3.1: Suzuki coupling;
DOI:10.1021/ol052956q

Reference yield:

: 7-Methoxy-6-methyl-1-[2-methyl-prop-(E)-ylidene]-indan

: 888328-91-4
3-[3-isobutyl-4-(1-isobutyl-7-methoxy-6-methyl-indan-4-yl)-phenyl]-propionitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: 0.36 g / hydrogen / Pd/C / 10 h / 760 Torr

2.1: 90 percent / acetic acid; NBS / 2 h / 85 °C

3.1: n-BuLi / tetrahydrofuran / 0.5 h / -75 °C

3.2: tetrahydrofuran / 24 h / 20 °C

3.3: NaOH / H₂O / 1 h

4.1: 0.30 g / Cs₂CO₃ / Pd(PPh₃)4 / dimethylformamide; H₂O / 2 h / 120 °C

With N-Bromosuccinimide; n-butyllithium; hydrogen; caesium carbonate; acetic acid; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; N,N-dimethyl-formamide; 4.1: Suzuki coupling;
DOI:10.1021/ol052956q