phenyl 2-((tert-butyldiphenylsilyloxy) methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-ylcarbamate

Base Information

• Chemical Name: phenyl 2-((tert-butyldiphenylsilyloxy) methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-ylcarbamate
• CAS No.: 1392513-46-0
• Molecular Formula: C₃₃H₃₇N₃O₆Si
• Molecular Weight: 599.759
• Mol file: 1392513-46-0.mol

Synonyms:phenyl 2-((tert-butyldiphenylsilyloxy) methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-ylcarbamate

Chemical Property of phenyl 2-((tert-butyldiphenylsilyloxy) methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-ylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phenyl 2-((tert-butyldiphenylsilyloxy) methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-ylcarbamate

There total 3 articles about phenyl 2-((tert-butyldiphenylsilyloxy) methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C26H33N3O4Si (1392513-45-9) + phenyl chloroformate (1885-14-9) → phenyl 2-((tert-butyldiphenylsilyloxy) methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-ylcarbamate (1392513-46-0)

Guidance literature:

With pyridine; In dichloromethane; for 16h; Reflux;

DOI:10.1016/j.bmc.2012.06.038

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → phenyl 2-((tert-butyldiphenylsilyloxy) methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-ylcarbamate (1392513-46-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 1H-imidazole / dichloromethane / Inert atmosphere

2: zinc; ammonium chloride / ethanol; water / Reflux

3: pyridine / dichloromethane / 16 h / Reflux

With pyridine; 1H-imidazole; ammonium chloride; zinc; In ethanol; dichloromethane; water;

DOI:10.1016/j.bmc.2012.06.038

Reference yield:

1-((2R,4S,5S)-4-azido-5-(((tert-butyldiphenylsilyl)oxy)methyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (116195-69-8) → phenyl 2-((tert-butyldiphenylsilyloxy) methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-ylcarbamate (1392513-46-0)

Guidance literature:

Multi-step reaction with 2 steps

1: zinc; ammonium chloride / ethanol; water / Reflux

2: pyridine / dichloromethane / 16 h / Reflux

With pyridine; ammonium chloride; zinc; In ethanol; dichloromethane; water;

DOI:10.1016/j.bmc.2012.06.038

upstream raw materials:

C₂₆H₃₃N₃O₄Si

phenyl chloroformate

1-((2R,4S,5S)-4-azido-5-(((tert-butyldiphenylsilyl)oxy)methyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

tert-butylchlorodiphenylsilane