ethyl 3-(3-(5-cyclobutoxy-2-fluorophenyl)-3-azaspiro[5.5]undecan-9-yl)propanoate

Base Information

Chemical Name:ethyl 3-(3-(5-cyclobutoxy-2-fluorophenyl)-3-azaspiro[5.5]undecan-9-yl)propanoate
CAS No.:1599479-05-6
Molecular Formula:C₂₅H₃₆FNO₃
Molecular Weight:417.564
Hs Code.:

Synonyms:ethyl 3-(3-(5-cyclobutoxy-2-fluorophenyl)-3-azaspiro[5.5]undecan-9-yl)propanoate

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Chemical Property of ethyl 3-(3-(5-cyclobutoxy-2-fluorophenyl)-3-azaspiro[5.5]undecan-9-yl)propanoate

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Technology Process of ethyl 3-(3-(5-cyclobutoxy-2-fluorophenyl)-3-azaspiro[5.5]undecan-9-yl)propanoate

There total 6 articles about ethyl 3-(3-(5-cyclobutoxy-2-fluorophenyl)-3-azaspiro[5.5]undecan-9-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 189334-35-8
ethyl 3-(3-azaspiro[5.5]undecan-9-yl)propanoate

: 1599479-36-3
2-bromo-4-cyclobutoxy-1-fluorobenzene

: 1599479-05-6
ethyl 3-(3-(5-cyclobutoxy-2-fluorophenyl)-3-azaspiro[5.5]undecan-9-yl)propanoate

Guidance literature:: With chloro(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1’-biphenyl)[2-(2’-amino-1,1‘-biphenyl)]palladium(II) 2nd generation; caesium carbonate; In 1,4-dioxane; at 110 ℃; for 72h; Microwave irradiation; Inert atmosphere; Sealed tube;

Reference yield:

: 873924-08-4
9-oxo-3-azaspiro[5.5]undecane-3-carboxylic acid tert-butyl ester

: 1599479-05-6
ethyl 3-(3-(5-cyclobutoxy-2-fluorophenyl)-3-azaspiro[5.5]undecan-9-yl)propanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium tert-butylate / tetrahydrofuran / 1 h / 20 °C

1.2: 1 h

2.1: water; hydrogenchloride / tetrahydrofuran / 20 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C

3.2: 1 h / 0 °C

4.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 3 h

5.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

6.1: chloro(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1’-biphenyl)[2-(2’-amino-1,1‘-biphenyl)]palladium(II) 2nd generation; caesium carbonate / 1,4-dioxane / 72 h / 110 °C / Microwave irradiation; Inert atmosphere; Sealed tube

With hydrogenchloride; palladium 10% on activated carbon; chloro(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1’-biphenyl)[2-(2’-amino-1,1‘-biphenyl)]palladium(II) 2nd generation; potassium tert-butylate; water; hydrogen; sodium hydride; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; ethyl acetate; mineral oil;

Reference yield:

: 1416176-13-0
tert-butyl 9-(methoxymethylidene)-3-azaspiro[5.5]undecane-3-carboxylate

: 1599479-05-6
ethyl 3-(3-(5-cyclobutoxy-2-fluorophenyl)-3-azaspiro[5.5]undecan-9-yl)propanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: water; hydrogenchloride / tetrahydrofuran / 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C

2.2: 1 h / 0 °C

3.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 3 h

4.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

5.1: chloro(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1’-biphenyl)[2-(2’-amino-1,1‘-biphenyl)]palladium(II) 2nd generation; caesium carbonate / 1,4-dioxane / 72 h / 110 °C / Microwave irradiation; Inert atmosphere; Sealed tube

With hydrogenchloride; palladium 10% on activated carbon; chloro(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1’-biphenyl)[2-(2’-amino-1,1‘-biphenyl)]palladium(II) 2nd generation; water; hydrogen; sodium hydride; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; ethyl acetate; mineral oil;