TERT-BUTYL 9-OXO-3-AZASPIRO[5.5]UNDECANE-3-CARBOXYLATE

Base Information

• Chemical Name: TERT-BUTYL 9-OXO-3-AZASPIRO[5.5]UNDECANE-3-CARBOXYLATE
• CAS No.: 873924-08-4
• Molecular Formula: C15H25NO3
• Molecular Weight: 267.368
• Hs Code.: 2933990090
• Mol file: 873924-08-4.mol

Synonyms:tert-butyl 9-oxo-3-azaspiro[5.5]undecane-3-carboxylate;

Chemical Property of TERT-BUTYL 9-OXO-3-AZASPIRO[5.5]UNDECANE-3-CARBOXYLATE

Chemical Property:

• Melting Point: 70-73 °C
• Boiling Point: 120 °C(Press: 0.02 Torr)
• PKA: -0.76±0.20(Predicted)
• PSA: 46.61000
• Density: 1.08±0.1 g/cm3(Predicted)
• LogP: 3.08470
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Boc-9-oxo-3-azaspiro[5.5]undecane 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: tert-Butyl 9-Oxo-3-azaspiro[5.5]undecane-3-carboxylate is used in preparation of benzothiazole derivatives as IRAK degraders and uses thereof.

Technology Process of TERT-BUTYL 9-OXO-3-AZASPIRO[5.5]UNDECANE-3-CARBOXYLATE

There total 20 articles about TERT-BUTYL 9-OXO-3-AZASPIRO[5.5]UNDECANE-3-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

9-oxo-3-azaspiro[5.5]undec-7-ene-3-carboxylic acid tert-butyl ester (873924-07-3) → 9-oxo-3-azaspiro[5.5]undecane-3-carboxylic acid tert-butyl ester (873924-08-4)

Guidance literature:

With hydrogen; palladium-on-charcoal; In methanol; at 25 ℃; for 16h; Product distribution / selectivity; Inert atmosphere;

Reference yield: 61.0%

di-tert-butyl dicarbonate (24424-99-5) + 3-oxo-9-azaspiro[5.5]undec-4-ene-9-carboxylic acid benzyl ester (189333-18-4) → 9-oxo-3-azaspiro[5.5]undecane-3-carboxylic acid tert-butyl ester (873924-08-4)

Guidance literature:

With palladium on activated charcoal; hydrogen; triethylamine; In methanol; for 5h;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + 3-azaspiro[5.5]undecan-9-one hydrochloride (1225437-09-1) → 9-oxo-3-azaspiro[5.5]undecane-3-carboxylic acid tert-butyl ester (873924-08-4)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

upstream raw materials:

di-tert-butyl dicarbonate

3-oxo-9-azaspiro[5.5]undec-4-ene-9-carboxylic acid benzyl ester

9-oxo-3-azaspiro[5.5]undec-7-ene-3-carboxylic acid tert-butyl ester

3-azaspiro[5.5]undecan-9-one hydrochloride

Downstream raw materials:

tert-butyl 9-hydroxy-3-azaspiro[5.5 ]undecane-3-carboxylate

9-(3,4-dichloro-phenylamino)-3-aza-spiro[5.5]undecane-3-carboxylic acid tert-butyl ester

tert-Butyl 9-(3-fluorophenyl)-9-(pyrrolidin-1-yl)-3-azaspiro[5.5]undecane-3-carboxylate

9-(3,3-Difluoroazetidin-1-yl)-9-phenyl-3-azaspiro[5.5]undecane

Refernces

• 1、 -. "SUBSTITUTED HETEROARYL COMPOUNDS AND METHODS OF USE". Paragraph 0441; 0467. . Retrieved 2017/03/28.
• 2、 -. "Substituted heteroaryl compounds and compositions and uses thereof". Paragraph 0539; 0540; 0541. . Retrieved 2017/12/27.