[¹⁸F]2-[3,5-bis(4-hydroxy-3-methoxystyryl)-1H-pyrazol-1-yl]-N-{1-[(2-(2-(2-fluoroethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl]methyl}acetamide

Base Information

• Chemical Name: [¹⁸F]2-[3,5-bis(4-hydroxy-3-methoxystyryl)-1H-pyrazol-1-yl]-N-{1-[(2-(2-(2-fluoroethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl]methyl}acetamide
• CAS No.: 1607456-21-2
• Molecular Formula: C₃₂H₃₇FN₆O₇
• Molecular Weight: 635.682

Synonyms:[¹⁸F]2-[3,5-bis(4-hydroxy-3-methoxystyryl)-1H-pyrazol-1-yl]-N-{1-[(2-(2-(2-fluoroethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl]methyl}acetamide

Chemical Property of [¹⁸F]2-[3,5-bis(4-hydroxy-3-methoxystyryl)-1H-pyrazol-1-yl]-N-{1-[(2-(2-(2-fluoroethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl]methyl}acetamide

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Technology Process of [¹⁸F]2-[3,5-bis(4-hydroxy-3-methoxystyryl)-1H-pyrazol-1-yl]-N-{1-[(2-(2-(2-fluoroethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl]methyl}acetamide

There total 2 articles about [¹⁸F]2-[3,5-bis(4-hydroxy-3-methoxystyryl)-1H-pyrazol-1-yl]-N-{1-[(2-(2-(2-fluoroethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl]methyl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[3,5-bis((E)-4-hydroxy-3-methoxystyryl)-1H-pyrazol-1-yl]-N-(prop-2-yn-1-yl)acetamide (1264718-62-8) + 1-azido-2-(2-(2-fluoroethoxy)ethoxy)ethane (1351974-21-4) → [18F]2-[3,5-bis(4-hydroxy-3-methoxystyryl)-1H-pyrazol-1-yl]-N-{1-[(2-(2-(2-fluoroethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl]methyl}acetamide (1607456-21-2)

Guidance literature:

With copper(ll) sulfate pentahydrate; Erythorbic acid; In water; dimethyl sulfoxide; at 20 ℃; for 0.25h;

DOI:10.1016/j.bmc.2014.03.010

Reference yield:

2-[2-(2-azidoethoxy)ethoxy]ethanol (86520-52-7) → [18F]2-[3,5-bis(4-hydroxy-3-methoxystyryl)-1H-pyrazol-1-yl]-N-{1-[(2-(2-(2-fluoroethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl]methyl}acetamide (1607456-21-2)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran; tert-butyl alcohol / 20 - 100 °C

3: Erythorbic acid; copper(ll) sulfate pentahydrate / water; dimethyl sulfoxide / 0.25 h / 20 °C

With copper(ll) sulfate pentahydrate; tetrabutyl ammonium fluoride; Erythorbic acid; triethylamine; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; tert-butyl alcohol;

DOI:10.1016/j.bmc.2014.03.010

upstream raw materials:

2-[3,5-bis((E)-4-hydroxy-3-methoxystyryl)-1H-pyrazol-1-yl]-N-(prop-2-yn-1-yl)acetamide

1-azido-2-(2-(2-fluoroethoxy)ethoxy)ethane

2-[2-(2-azidoethoxy)ethoxy]ethanol

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