methyl 2-((4-(quinolin-7-yl)-3-methyl-1-(2-methylphenyl)-1H-pyrazol-5-yl)amino)benzenecarboxylate

Base Information

• Chemical Name: methyl 2-((4-(quinolin-7-yl)-3-methyl-1-(2-methylphenyl)-1H-pyrazol-5-yl)amino)benzenecarboxylate
• CAS No.: 1210047-83-8
• Molecular Formula: C₂₈H₂₄N₄O₂
• Molecular Weight: 448.524
• Mol file: 1210047-83-8.mol

Synonyms:methyl 2-((4-(quinolin-7-yl)-3-methyl-1-(2-methylphenyl)-1H-pyrazol-5-yl)amino)benzenecarboxylate

Chemical Property of methyl 2-((4-(quinolin-7-yl)-3-methyl-1-(2-methylphenyl)-1H-pyrazol-5-yl)amino)benzenecarboxylate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of methyl 2-((4-(quinolin-7-yl)-3-methyl-1-(2-methylphenyl)-1H-pyrazol-5-yl)amino)benzenecarboxylate

There total 1 articles about methyl 2-((4-(quinolin-7-yl)-3-methyl-1-(2-methylphenyl)-1H-pyrazol-5-yl)amino)benzenecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinoline (851985-81-4) + methyl 2-((4-bromo-3-methyl-1-(2-methylphenyl)-1H-pyrazol-5-yl)amino)benzenecarboxylate (1209485-74-4) → methyl 2-((4-(quinolin-7-yl)-3-methyl-1-(2-methylphenyl)-1H-pyrazol-5-yl)amino)benzenecarboxylate (1210047-83-8)

Guidance literature:

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; at 100 ℃; Inert atmosphere;

Reference yield: 70.0%

methyl 2-((4-(quinolin-7-yl)-3-methyl-1-(2-methylphenyl)-1H-pyrazol-5-yl)amino)benzenecarboxylate (1210047-83-8) → 2-((4-(quinolin-7-yl)-3-methyl-1-(2-methylphenyl)-1H-pyrazol-5-yl)amino)benzoic acid (1210048-88-6)

Guidance literature:

methyl 2-((4-(quinolin-7-yl)-3-methyl-1-(2-methylphenyl)-1H-pyrazol-5-yl)amino)benzenecarboxylate; With water; sodium hydroxide; In 1,4-dioxane; at 20 - 60 ℃;

With hydrogenchloride; In water;

upstream raw materials:

7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinoline

methyl 2-((4-bromo-3-methyl-1-(2-methylphenyl)-1H-pyrazol-5-yl)amino)benzenecarboxylate

Downstream raw materials:

2-((4-(quinolin-7-yl)-3-methyl-1-(2-methylphenyl)-1H-pyrazol-5-yl)amino)benzoic acid