methyl 2-((4-bromo-3-methyl-1-(2-methylphenyl)-1H-pyrazol-5-yl)amino)benzenecarboxylate

Base Information

• Chemical Name: methyl 2-((4-bromo-3-methyl-1-(2-methylphenyl)-1H-pyrazol-5-yl)amino)benzenecarboxylate
• CAS No.: 1209485-74-4
• Molecular Formula: C₁₉H₁₈BrN₃O₂
• Molecular Weight: 400.275
• Mol file: 1209485-74-4.mol

Synonyms:methyl 2-((4-bromo-3-methyl-1-(2-methylphenyl)-1H-pyrazol-5-yl)amino)benzenecarboxylate

Chemical Property of methyl 2-((4-bromo-3-methyl-1-(2-methylphenyl)-1H-pyrazol-5-yl)amino)benzenecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of methyl 2-((4-bromo-3-methyl-1-(2-methylphenyl)-1H-pyrazol-5-yl)amino)benzenecarboxylate

There total 1 articles about methyl 2-((4-bromo-3-methyl-1-(2-methylphenyl)-1H-pyrazol-5-yl)amino)benzenecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methyl 2-((3-methyl-1-(2-methylphenyl)-1H-pyrazol-5-yl)amino)benzenecarboxylate (1209485-73-3) → methyl 2-((4-bromo-3-methyl-1-(2-methylphenyl)-1H-pyrazol-5-yl)amino)benzenecarboxylate (1209485-74-4)

Guidance literature:

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; In dichloromethane; for 0.166667h; Coolin with ice;

Reference yield: 94.0%

5-fluoro-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinoxaline (1210048-06-8) + methyl 2-((4-bromo-3-methyl-1-(2-methylphenyl)-1H-pyrazol-5-yl)amino)benzenecarboxylate (1209485-74-4) → methyl 2-((4-(8-fluoroquinoxalin-6-yl)-3-methyl-1-(2-methylphenyl)-1H-pyrazol-5-yl)amino)benzenecarboxylate (1210048-08-0)

Guidance literature:

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; water; at 100 ℃; for 2h; Inert atmosphere;

Reference yield: 56.0%

7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)[1,2,4]triazolo[1,5-a]pyridin.2.amine (1210048-24-0) + methyl 2-((4-bromo-3-methyl-1-(2-methylphenyl)-1H-pyrazol-5-yl)amino)benzenecarboxylate (1209485-74-4) → methyl 2-((4-(2-amino[1,2,4]triazolo[1,5-a]pyridin-7-yl)-3-methyl-1-(2-methylphenyl)-1H-pyrazol-5-yl)amino)benzenecarboxylate (1210048-25-1)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; at 110 ℃; for 4h; Inert atmosphere;

upstream raw materials:

methyl 2-((3-methyl-1-(2-methylphenyl)-1H-pyrazol-5-yl)amino)benzenecarboxylate

Downstream raw materials:

methyl 2-((4-(5-fluoroquinazolin-7-yl)-3-methyl-1-(2-methylphenyl)-1H-pyrazol-5-yl)amino)benzenecarboxylate

methyl 2-((4-(quinolin-7-yl)-3-methyl-1-(2-methylphenyl)-1H-pyrazol-5-yl)amino)benzenecarboxylate

methyl 2-((4-(8-fluoro-7-methoxyquinoxalin-6-yl)-3-methyl-1-(2-methylphenyl)-1H-pyrazol-5-yl)amino)benzenecarboxylate

methyl 2-((4-(3-methoxyquinoxalin-6-yl)-3-methyl-1-(2-methylphenyl)-1H-pyrazol-5-yl)amino)benzenecarboxylate