5-chloro-4-{[5-chloro-6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]oxy}-2-fluoro-N-(methanesulfonyl)benzamide

Base Information

Chemical Name:5-chloro-4-{[5-chloro-6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]oxy}-2-fluoro-N-(methanesulfonyl)benzamide
CAS No.:1355063-69-2
Molecular Formula:C₁₆H₁₁Cl₂F₅N₂O₅S
Molecular Weight:509.238
Hs Code.:

Synonyms:5-chloro-4-{[5-chloro-6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]oxy}-2-fluoro-N-(methanesulfonyl)benzamide

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Chemical Property of 5-chloro-4-{[5-chloro-6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]oxy}-2-fluoro-N-(methanesulfonyl)benzamide

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Technology Process of 5-chloro-4-{[5-chloro-6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]oxy}-2-fluoro-N-(methanesulfonyl)benzamide

There total 8 articles about 5-chloro-4-{[5-chloro-6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]oxy}-2-fluoro-N-(methanesulfonyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 3144-09-0
methanesulfonamide

: 1355067-26-3
5-chloro-4-((5-chloro-6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl)oxy)-2-fluorobenzoic acid

: 1355063-69-2
5-chloro-4-{[5-chloro-6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]oxy}-2-fluoro-N-(methanesulfonyl)benzamide

Guidance literature:: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethyl acetate; for 18h; Product distribution / selectivity; Reflux;

Reference yield:

: 5-chloro-2,4-difluorobenzoic acid

: 1355063-69-2
5-chloro-4-{[5-chloro-6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]oxy}-2-fluoro-N-(methanesulfonyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: dmap / tert-butyl alcohol / 64 h / 45 °C / Inert atmosphere

2: potassium carbonate / dimethyl sulfoxide / 3 h / 20 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate; tetrahydrofuran / 18 h / Reflux

With potassium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; dmap; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; ethyl acetate; tert-butyl alcohol;

Reference yield:

: 1355067-32-1
3-chloro-2-(2,2,3,3-tetrafluoropropyl)pyridine

: 1355063-69-2
5-chloro-4-{[5-chloro-6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl]oxy}-2-fluoro-N-(methanesulfonyl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 4,4'-di-tert-butyl-2,2'-bipyridine; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / n-heptane / 16 h / 20 °C / Inert atmosphere

2: dihydrogen peroxide / water; methanol / 4 h / 0 - 20 °C

3: potassium carbonate / dimethyl sulfoxide / 3 h / 20 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

5: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate; tetrahydrofuran / 18 h / Reflux

With dihydrogen peroxide; potassium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine; In tetrahydrofuran; methanol; n-heptane; dichloromethane; water; dimethyl sulfoxide; ethyl acetate;