tert-butyl 5-chloro-4-(5-chloro-6-(2,2,3,3-tetrafluoropropoxy)-pyridin-3-yloxy)-2-fluorobenzoate

Base Information

Chemical Name:tert-butyl 5-chloro-4-(5-chloro-6-(2,2,3,3-tetrafluoropropoxy)-pyridin-3-yloxy)-2-fluorobenzoate
CAS No.:1355067-24-1
Molecular Formula:C₁₉H₁₆Cl₂F₅NO₄
Molecular Weight:488.238
Hs Code.:

Synonyms:tert-butyl 5-chloro-4-(5-chloro-6-(2,2,3,3-tetrafluoropropoxy)-pyridin-3-yloxy)-2-fluorobenzoate

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Chemical Property of tert-butyl 5-chloro-4-(5-chloro-6-(2,2,3,3-tetrafluoropropoxy)-pyridin-3-yloxy)-2-fluorobenzoate

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Technology Process of tert-butyl 5-chloro-4-(5-chloro-6-(2,2,3,3-tetrafluoropropoxy)-pyridin-3-yloxy)-2-fluorobenzoate

There total 5 articles about tert-butyl 5-chloro-4-(5-chloro-6-(2,2,3,3-tetrafluoropropoxy)-pyridin-3-yloxy)-2-fluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1354961-13-9
tert-butyl-5-chloro-2,4-di-fluorobenzoate

: 1355067-28-5
5-chloro-6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-ol

: 1355067-24-1
tert-butyl 5-chloro-4-(5-chloro-6-(2,2,3,3-tetrafluoropropoxy)-pyridin-3-yloxy)-2-fluorobenzoate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 5-chloro-2,4-difluorobenzoic acid

: 1355067-24-1
tert-butyl 5-chloro-4-(5-chloro-6-(2,2,3,3-tetrafluoropropoxy)-pyridin-3-yloxy)-2-fluorobenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: dmap / tert-butyl alcohol / 64 h / 45 °C / Inert atmosphere

2: potassium carbonate / dimethyl sulfoxide / 3 h / 20 °C / Inert atmosphere

With potassium carbonate; dmap; In dimethyl sulfoxide; tert-butyl alcohol;

Reference yield:

: 2402-77-9
2,3-dichloro-pyridine

: 1355067-24-1
tert-butyl 5-chloro-4-(5-chloro-6-(2,2,3,3-tetrafluoropropoxy)-pyridin-3-yloxy)-2-fluorobenzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 - 20 °C

1.2: 16 h / Reflux

2.1: 4,4'-di-tert-butyl-2,2'-bipyridine; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / n-heptane / 16 h / 20 °C / Inert atmosphere

3.1: dihydrogen peroxide / water; methanol / 4 h / 0 - 20 °C

4.1: potassium carbonate / dimethyl sulfoxide / 3 h / 20 °C / Inert atmosphere

With dihydrogen peroxide; sodium hydride; potassium carbonate; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine; In tetrahydrofuran; methanol; n-heptane; water; dimethyl sulfoxide; mineral oil;