(S)-N-((4'-chlorobiphenyl-2-yl)(piperidin-4-yl)methyl)-2-methylpropane-2-sulfinamide trifluoroacetate

Base Information

Chemical Name:(S)-N-((4'-chlorobiphenyl-2-yl)(piperidin-4-yl)methyl)-2-methylpropane-2-sulfinamide trifluoroacetate
CAS No.:1357577-26-4
Molecular Formula:C₂HF₃O₂*C₂₂H₂₉ClN₂OS
Molecular Weight:519.028
Hs Code.:

Synonyms:(S)-N-((4'-chlorobiphenyl-2-yl)(piperidin-4-yl)methyl)-2-methylpropane-2-sulfinamide trifluoroacetate

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Chemical Property of (S)-N-((4'-chlorobiphenyl-2-yl)(piperidin-4-yl)methyl)-2-methylpropane-2-sulfinamide trifluoroacetate

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Technology Process of (S)-N-((4'-chlorobiphenyl-2-yl)(piperidin-4-yl)methyl)-2-methylpropane-2-sulfinamide trifluoroacetate

There total 4 articles about (S)-N-((4'-chlorobiphenyl-2-yl)(piperidin-4-yl)methyl)-2-methylpropane-2-sulfinamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1357577-24-2
tert-butyl 4-((4'-chlorobiphenyl-2-yl)((S)-1,1-dimethylethylsulfinamido)methyl)piperidine-1-carboxylate

: 76-05-1
trifluoroacetic acid

: 1357577-26-4
(S)-N-((4'-chlorobiphenyl-2-yl)(piperidin-4-yl)methyl)-2-methylpropane-2-sulfinamide trifluoroacetate

Guidance literature:: In dichloromethane; at 18 - 25 ℃; for 1h;

Reference yield:

: 137076-22-3
tert butyl 4-formylpiperidine-1-carboxylate

: 1357577-26-4
(S)-N-((4'-chlorobiphenyl-2-yl)(piperidin-4-yl)methyl)-2-methylpropane-2-sulfinamide trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 2 h / 18 - 25 °C

2.1: TurboGrignard / tetrahydrofuran / 2 h / -15 °C

2.2: -15 °C

3.1: potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / toluene; water / 5 h / 100 °C

4.1: dichloromethane / 1 h / 18 - 25 °C

With titanium(IV) tetraethanolate; potassium phosphate; TurboGrignard; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; water; toluene;

Reference yield:

: 1097880-26-6
tert-butyl 4-[(E)-{[(S)-2-methylpropane-2-sulfinyl]imino}methyl]piperidine-1-carboxylate

: 1357577-26-4
(S)-N-((4'-chlorobiphenyl-2-yl)(piperidin-4-yl)methyl)-2-methylpropane-2-sulfinamide trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: TurboGrignard / tetrahydrofuran / 2 h / -15 °C

1.2: -15 °C

2.1: potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / toluene; water / 5 h / 100 °C

3.1: dichloromethane / 1 h / 18 - 25 °C

With potassium phosphate; TurboGrignard; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; water; toluene;