4-(4-{3-[(dimethylamino)methy1]-5-fluorophenoxy} piperidin-1-yl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]butanenitrile

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Chemical Name:4-(4-{3-[(dimethylamino)methy1]-5-fluorophenoxy} piperidin-1-yl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]butanenitrile
CAS No.:1377323-72-2
Molecular Formula:C₂₇H₃₁FN₈O
Molecular Weight:502.595
Hs Code.:

Synonyms:4-(4-{3-[(dimethylamino)methy1]-5-fluorophenoxy} piperidin-1-yl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]butanenitrile

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Chemical Property of 4-(4-{3-[(dimethylamino)methy1]-5-fluorophenoxy} piperidin-1-yl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]butanenitrile

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Technology Process of 4-(4-{3-[(dimethylamino)methy1]-5-fluorophenoxy} piperidin-1-yl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]butanenitrile

There total 9 articles about 4-(4-{3-[(dimethylamino)methy1]-5-fluorophenoxy} piperidin-1-yl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]butanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1377323-80-2
3-[(dimethylamino)methyl]-5-fluorophenol

: 1377323-77-7
4-(4-hydroxypiperidin-1-yl)-3-[4-(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]butanenitrile

: 1377323-72-2
4-(4-{3-[(dimethylamino)methy1]-5-fluorophenoxy} piperidin-1-yl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]butanenitrile

Guidance literature:: With di-tert-butyl-diazodicarboxylate; triphenylphosphine; In dichloromethane; at 20 ℃; for 2.33h;

Reference yield:

: C₃₃H₄₅FN₈O₂Si

: 1377323-72-2
4-(4-{3-[(dimethylamino)methy1]-5-fluorophenoxy} piperidin-1-yl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]butanenitrile

Guidance literature:: C₃₃H₄₅FN₈O₂Si; With trifluoroacetic acid; In dichloromethane; for 2h;

With ethylenediamine; In methanol;

Reference yield:

: 473923-95-4
3-fluoro-5-hydroxy-benzonitrile

: 1377323-72-2
4-(4-{3-[(dimethylamino)methy1]-5-fluorophenoxy} piperidin-1-yl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]butanenitrile

Guidance literature:: Multi-step reaction with 3 steps

1: diisobutylaluminium hydride / toluene / 1 h / -78 - 20 °C

2: triethylamine; sodium tris(acetoxy)borohydride / dichloromethane

3: triphenylphosphine; di-tert-butyl-diazodicarboxylate / dichloromethane / 2.33 h / 20 °C

With di-tert-butyl-diazodicarboxylate; sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; triethylamine; triphenylphosphine; In dichloromethane; toluene;