3-[N¹-phenoxycarbonylhydrazido][N²-(tert-butoxycarbonyl)hydrazino]-N,N-dimethylpropanamide

Base Information

• Chemical Name: 3-[N¹-phenoxycarbonylhydrazido][N²-(tert-butoxycarbonyl)hydrazino]-N,N-dimethylpropanamide
• CAS No.: 255873-60-0
• Molecular Formula: C₁₈H₂₇N₅O₆
• Molecular Weight: 409.442

Synonyms:3-[N¹-phenoxycarbonylhydrazido][N²-(tert-butoxycarbonyl)hydrazino]-N,N-dimethylpropanamide

Chemical Property of 3-[N¹-phenoxycarbonylhydrazido][N²-(tert-butoxycarbonyl)hydrazino]-N,N-dimethylpropanamide

Chemical Property:

Purity/Quality:

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Technology Process of 3-[N¹-phenoxycarbonylhydrazido][N²-(tert-butoxycarbonyl)hydrazino]-N,N-dimethylpropanamide

There total 5 articles about 3-[N¹-phenoxycarbonylhydrazido][N²-(tert-butoxycarbonyl)hydrazino]-N,N-dimethylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

1,2-hydrazinedicarboxylic acid diphenyl ester (10465-98-2) + 3-[N2-(tert-butoxycarbonyl)hydrazino]-N,N-dimethylpropanamide (255873-58-6) → 3-[N1-phenoxycarbonylhydrazido][N2-(tert-butoxycarbonyl)hydrazino]-N,N-dimethylpropanamide (255873-60-0)

Guidance literature:

With triethylamine; In chloroform; for 3h; Heating;

DOI:10.1021/jo9915123

Reference yield:

N,N-Dimethylacrylamide (2680-03-7,68761-83-1) → 3-[N1-phenoxycarbonylhydrazido][N2-(tert-butoxycarbonyl)hydrazino]-N,N-dimethylpropanamide (255873-60-0)

Guidance literature:

Multi-step reaction with 5 steps

1: hydrazine monohydrate / methanol / 2 h

2: 5.91 g / sodium hydroxide / diethyl ether; H₂O / 1 h

3: 76 percent / 4-(dimethylamino)pyridine / acetonitrile / 20 °C

4: 97 percent / hydrogen / Pd/C / methanol / 4 h

5: 43 percent / triethylamine / CHCl₃ / 3 h / Heating

With dmap; sodium hydroxide; hydrogen; hydrazine hydrate; triethylamine; palladium on activated charcoal; In methanol; diethyl ether; chloroform; water; acetonitrile; 1: Addition / 2: Acylation / 3: Acylation / 4: Catalytic hydrogenation / 5: Acylation;

DOI:10.1021/jo9915123

Reference yield:

3-hydrazino-N,N-(dimethyl)propanamide (107746-30-5) → 3-[N1-phenoxycarbonylhydrazido][N2-(tert-butoxycarbonyl)hydrazino]-N,N-dimethylpropanamide (255873-60-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 5.91 g / sodium hydroxide / diethyl ether; H₂O / 1 h

2: 76 percent / 4-(dimethylamino)pyridine / acetonitrile / 20 °C

3: 97 percent / hydrogen / Pd/C / methanol / 4 h

4: 43 percent / triethylamine / CHCl₃ / 3 h / Heating

With dmap; sodium hydroxide; hydrogen; triethylamine; palladium on activated charcoal; In methanol; diethyl ether; chloroform; water; acetonitrile; 1: Acylation / 2: Acylation / 3: Catalytic hydrogenation / 4: Acylation;

DOI:10.1021/jo9915123

upstream raw materials:

1,2-hydrazinedicarboxylic acid diphenyl ester

3-[N²-(tert-butoxycarbonyl)hydrazino]-N,N-dimethylpropanamide

N,N-Dimethylacrylamide

3-hydrazino-N,N-(dimethyl)propanamide

Downstream raw materials:

N-(4S-benzyl-2,5-dioxoimidazolidin-1-yl)-N-(tert-butoxycarbonylhydrazino)-N,N-dimethylpropanamide urea

3-[N¹-phenethylamidohydrazido][(N²-tert-butoxycarbonyl)hydrazino]-N,N-dimethylpropanamide

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