Technology Process of lithium 6-fluoro-1-(phenylsulfonyl)-1H-indole-2-sulfinate
There total 6 articles about lithium 6-fluoro-1-(phenylsulfonyl)-1H-indole-2-sulfinate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
6-fluoro-1-(phenylsulfonyl)-1H-indole;
With
n-butyllithium;
In
tetrahydrofuran;
at -70 ℃;
for 0.5h;
Inert atmosphere;
With
sulfur dioxide;
at -70 - 20 ℃;
for 2.25h;
Inert atmosphere;
DOI:10.1016/j.bmcl.2016.08.018
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: toluene-4-sulfonic acid / 20 h / Reflux
2.1: sodium hydroxide / ethanol / 40 °C
2.2: 0.42 h / 250 °C / Microwave irradiation
3.1: sodium hydride / N,N-dimethyl-formamide / 18 h / 20 °C
4.1: n-butyllithium / tetrahydrofuran / 0.5 h / -70 °C / Inert atmosphere
4.2: 2.25 h / -70 - 20 °C / Inert atmosphere
With
n-butyllithium; sodium hydride; toluene-4-sulfonic acid; sodium hydroxide;
In
tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2016.08.018
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydroxide / ethanol / 40 °C
1.2: 0.42 h / 250 °C / Microwave irradiation
2.1: sodium hydride / N,N-dimethyl-formamide / 18 h / 20 °C
3.1: n-butyllithium / tetrahydrofuran / 0.5 h / -70 °C / Inert atmosphere
3.2: 2.25 h / -70 - 20 °C / Inert atmosphere
With
n-butyllithium; sodium hydride; sodium hydroxide;
In
tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2016.08.018
