N-[(17-benzyl-6β,14β-epoxy-3-hydroxymorphinan-6α-yl)methyl]-4-hydroxybenzamide

Base Information

Chemical Name:N-[(17-benzyl-6β,14β-epoxy-3-hydroxymorphinan-6α-yl)methyl]-4-hydroxybenzamide
CAS No.:1130021-23-6
Molecular Formula:C₃₁H₃₂N₂O₄
Molecular Weight:496.606
Hs Code.:

Synonyms:N-[(17-benzyl-6β,14β-epoxy-3-hydroxymorphinan-6α-yl)methyl]-4-hydroxybenzamide

Suppliers and Price of N-[(17-benzyl-6β,14β-epoxy-3-hydroxymorphinan-6α-yl)methyl]-4-hydroxybenzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-[(17-benzyl-6β,14β-epoxy-3-hydroxymorphinan-6α-yl)methyl]-4-hydroxybenzamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-[(17-benzyl-6β,14β-epoxy-3-hydroxymorphinan-6α-yl)methyl]-4-hydroxybenzamide

There total 7 articles about N-[(17-benzyl-6β,14β-epoxy-3-hydroxymorphinan-6α-yl)methyl]-4-hydroxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1272675-74-7
N-[(17-benzyl-6β,14β-epoxy-3-methoxymorphinan-6α-yl)methyl]-4-methoxybenzamide

: 1130021-23-6
N-[(17-benzyl-6β,14β-epoxy-3-hydroxymorphinan-6α-yl)methyl]-4-hydroxybenzamide

Guidance literature:: With 1-thiopropane; potassium tert-butylate; In N,N-dimethyl-formamide; at 150 ℃;
DOI:10.1016/j.bmc.2010.12.035

Reference yield:

: 1103501-77-4
C₂₂H₂₈N₄O₂

: 1130021-23-6
N-[(17-benzyl-6β,14β-epoxy-3-hydroxymorphinan-6α-yl)methyl]-4-hydroxybenzamide

Guidance literature:: Multi-step reaction with 8 steps

1: palladium 10% on activated carbon; camphor-10-sulfonic acid; hydrogen / methanol / 12 h / 20 °C

2: pyridine / 3 h / 20 °C / Inert atmosphere

3: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 2 h / 20 °C / Inert atmosphere

4: acetic acid; zinc / 6 h / 20 °C / Inert atmosphere

5: potassium carbonate / N,N-dimethyl-formamide / 0.67 h / 20 °C / Inert atmosphere

6: hydrogenchloride; water / methanol / 8 h / 60 °C / Inert atmosphere

7: triethylamine / tetrahydrofuran / 0 °C / Inert atmosphere

8: 1-thiopropane; potassium tert-butylate / N,N-dimethyl-formamide / 150 °C

With pyridine; hydrogenchloride; 1-thiopropane; palladium 10% on activated carbon; camphor-10-sulfonic acid; potassium tert-butylate; water; hydrogen; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; potassium carbonate; acetic acid; triethylamine; zinc; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2010.12.035

Reference yield:

: 1130020-84-6
t-butyl N-[(6β,14β-epoxy-3-methoxy-17-(2,2,2-trichloroethoxycarbonyl)morphinan-6α-yl)methyl]carbamate

: 1130021-23-6
N-[(17-benzyl-6β,14β-epoxy-3-hydroxymorphinan-6α-yl)methyl]-4-hydroxybenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid; zinc / 6 h / 20 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 0.67 h / 20 °C / Inert atmosphere

3: hydrogenchloride; water / methanol / 8 h / 60 °C / Inert atmosphere

4: triethylamine / tetrahydrofuran / 0 °C / Inert atmosphere

5: 1-thiopropane; potassium tert-butylate / N,N-dimethyl-formamide / 150 °C

With hydrogenchloride; 1-thiopropane; potassium tert-butylate; water; potassium carbonate; acetic acid; triethylamine; zinc; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2010.12.035