t-butyl N-[(17-benzyl-6β,14β-epoxy-3-methoxymorphinan-6α-yl)methyl]carbamate

Base Information

Chemical Name:t-butyl N-[(17-benzyl-6β,14β-epoxy-3-methoxymorphinan-6α-yl)methyl]carbamate
CAS No.:1130020-86-8
Molecular Formula:C₃₀H₃₈N₂O₄
Molecular Weight:490.643
Hs Code.:

Synonyms:t-butyl N-[(17-benzyl-6β,14β-epoxy-3-methoxymorphinan-6α-yl)methyl]carbamate

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Chemical Property of t-butyl N-[(17-benzyl-6β,14β-epoxy-3-methoxymorphinan-6α-yl)methyl]carbamate

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Technology Process of t-butyl N-[(17-benzyl-6β,14β-epoxy-3-methoxymorphinan-6α-yl)methyl]carbamate

There total 5 articles about t-butyl N-[(17-benzyl-6β,14β-epoxy-3-methoxymorphinan-6α-yl)methyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1130020-85-7
t-butyl N-[(6β,14β-epoxy-3-methoxymorphinan-6α-yl)methyl]carbamate

: 100-39-0
benzyl bromide

: 1130020-86-8
t-butyl N-[(17-benzyl-6β,14β-epoxy-3-methoxymorphinan-6α-yl)methyl]carbamate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.666667h; Inert atmosphere;
DOI:10.1016/j.bmc.2010.12.035

Reference yield:

: 1103501-77-4
C₂₂H₂₈N₄O₂

: 1130020-86-8
t-butyl N-[(17-benzyl-6β,14β-epoxy-3-methoxymorphinan-6α-yl)methyl]carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: palladium 10% on activated carbon; camphor-10-sulfonic acid; hydrogen / methanol / 12 h / 20 °C

2: pyridine / 3 h / 20 °C / Inert atmosphere

3: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 2 h / 20 °C / Inert atmosphere

4: acetic acid; zinc / 6 h / 20 °C / Inert atmosphere

5: potassium carbonate / N,N-dimethyl-formamide / 0.67 h / 20 °C / Inert atmosphere

With pyridine; palladium 10% on activated carbon; camphor-10-sulfonic acid; hydrogen; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; potassium carbonate; acetic acid; zinc; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2010.12.035

Reference yield:

: 1103501-78-5
(17-cyclopropylmethyl-6β,14β-epoxy-3-methoxymorphinan-6α-yl)methanamine

: 1130020-86-8
t-butyl N-[(17-benzyl-6β,14β-epoxy-3-methoxymorphinan-6α-yl)methyl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 3 h / 20 °C / Inert atmosphere

2: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 2 h / 20 °C / Inert atmosphere

3: acetic acid; zinc / 6 h / 20 °C / Inert atmosphere

4: potassium carbonate / N,N-dimethyl-formamide / 0.67 h / 20 °C / Inert atmosphere

With pyridine; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; potassium carbonate; acetic acid; zinc; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2010.12.035