(E)-cinnamyl 3-(1,3-dibenzyl-2-oxo-2,3-dihydro-1H-imidazol-4-yl)-3-hydroxypropionate

Base Information

Chemical Name:(E)-cinnamyl 3-(1,3-dibenzyl-2-oxo-2,3-dihydro-1H-imidazol-4-yl)-3-hydroxypropionate
CAS No.:908597-53-5
Molecular Formula:C₂₉H₂₈N₂O₄
Molecular Weight:468.552
Hs Code.:

Synonyms:(E)-cinnamyl 3-(1,3-dibenzyl-2-oxo-2,3-dihydro-1H-imidazol-4-yl)-3-hydroxypropionate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-cinnamyl 3-(1,3-dibenzyl-2-oxo-2,3-dihydro-1H-imidazol-4-yl)-3-hydroxypropionate

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Technology Process of (E)-cinnamyl 3-(1,3-dibenzyl-2-oxo-2,3-dihydro-1H-imidazol-4-yl)-3-hydroxypropionate

There total 2 articles about (E)-cinnamyl 3-(1,3-dibenzyl-2-oxo-2,3-dihydro-1H-imidazol-4-yl)-3-hydroxypropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 21040-45-9
Cinnamyl acetate

: 896140-76-4
1,3-bis(benzyl)-4-formyl-2,3-dihydro-1H-imidazol-2-one

: 908597-53-5
(E)-cinnamyl 3-(1,3-dibenzyl-2-oxo-2,3-dihydro-1H-imidazol-4-yl)-3-hydroxypropionate

Guidance literature:: Cinnamyl acetate; With lithium hexamethyldisilazane; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

1,3-bis(benzyl)-4-formyl-2,3-dihydro-1H-imidazol-2-one; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;
DOI:10.1002/anie.200601208

Reference yield:

: 100-39-0
benzyl bromide

: 908597-53-5
(E)-cinnamyl 3-(1,3-dibenzyl-2-oxo-2,3-dihydro-1H-imidazol-4-yl)-3-hydroxypropionate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / 2 h / 23 °C

1.2: copper(II) chloride; sodium hydride; oxygen / dimethylformamide / 12 h / 80 °C

1.3: 99 percent / phosphorus oxychloride / dimethylformamide / 2.5 h / 0 - 23 °C

2.1: lithium hexamethyldisilazide / tetrahydrofuran; hexane / 0.5 h / -78 °C

2.2: 76 percent / tetrahydrofuran; hexane / 0.5 h / -78 °C

With sodium hydride; lithium hexamethyldisilazane; In tetrahydrofuran; hexane;
DOI:10.1002/anie.200601208

Reference yield:

: 908597-53-5
(E)-cinnamyl 3-(1,3-dibenzyl-2-oxo-2,3-dihydro-1H-imidazol-4-yl)-3-hydroxypropionate

: 908597-28-4
(E)-cinnamyl 3-(1,3-dibenzyl-2-oxo-2,3-dihydro-1H-imidazol-4-yl)-2-methyl-3-oxopropionate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 81 percent / Dess-Martin periodinane / CH₂Cl₂; H₂O / 0.17 h / 23 °C

2.1: sodium hydride / tetrahydrofuran / 2 h / 0 - 23 °C

2.2: 80 percent / tetrahydrofuran / 6 h / 23 °C

With sodium hydride; Dess-Martin periodane; In tetrahydrofuran; dichloromethane; water;
DOI:10.1002/anie.200601208